2. Immunology/Inflammation
  3. NO Synthase Interleukin Related
  4. iNOs-IN-1

iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects.

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iNOs-IN-1 Chemical Structure

iNOs-IN-1 Chemical Structure

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1 mg USD 100 In-stock
5 mg USD 300 In-stock
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50 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

iNOs-IN-1 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE iNOs-IN-1

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  • Purity & Documentation

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  • Customer Review

Description

iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects[1].

IC50 & Target

iNOS

 

IL-6

 

In Vitro

iNOs-IN-1 (YPW) (12.5, 25 and 50 µM; 2 hours) can significantly reduce NO production in LPS-treated RAW 264.7 cells[1].
iNOs-IN-1 (12.5, 25 and 50 µM; 2 hours) inhibits IL-6 production and iNOS protein expression in LPS-treated RAW 264.7 mouse macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

iNOs-IN-1 Related Antibodies

Western Blot Analysis

Cell Line: RAW 264.7 mouse macrophages[1]
Concentration: 12.5, 25 and 50 µM
Incubation Time: 2 hours
Result: Had a significant inhibitory effect on LPS-induced iNOS expression at 50 μM (p＜0.01).
Molecular Weight

464.51

Formula

C25H28N4O5
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=C(C=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (107.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (107.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1528 mL 10.7640 mL 21.5281 mL
5 mM 0.4306 mL 2.1528 mL 4.3056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.1528 mL 10.7640 mL 21.5281 mL 53.8202 mL
5 mM 0.4306 mL 2.1528 mL 4.3056 mL 10.7640 mL
10 mM 0.2153 mL 1.0764 mL 2.1528 mL 5.3820 mL
15 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
20 mM 0.1076 mL 0.5382 mL 1.0764 mL 2.6910 mL
25 mM 0.0861 mL 0.4306 mL 0.8611 mL 2.1528 mL
30 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
40 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3455 mL
50 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
60 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
80 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
100 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5382 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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iNOs-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iNOs-IN-1NO SynthaseInterleukin RelatedNitric oxide synthasesNOSILInflammationiNOSNitric OxideIL-6RAW 264.7PeptideInhibitorinhibitorinhibit

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