1. Metabolic Enzyme/Protease
    Stem Cell/Wnt
    PI3K/Akt/mTOR
  2. Phosphodiesterase (PDE)
    GSK-3
  3. VP3.15

VP3.15 

Cat. No.: HY-128879
Handling Instructions

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

For research use only. We do not sell to patients.

VP3.15 Chemical Structure

VP3.15 Chemical Structure

CAS No. : 1281681-54-6

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Description

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].

IC50 & Target

IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]

Molecular Weight

366.48

Formula

C₂₀H₂₂N₄OS

CAS No.

1281681-54-6

SMILES

N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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VP3.15
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