1281681-54-6
Chemical Structure
VP3.15
- CAS No.: 1281681-54-6
- Formula:C20H22N4OS
- Molecular Weight:366.48
IUPAC Name: (Z)-N-(2-morpholinoethyl)-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine
InChIKey: DUDNZBPCJBAIFT-MRCUWXFGSA-N
SMILES: N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1
Biological Activity: VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].
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VP3.15 | VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). | |||||||||||||||||||||
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Keywords
