Isoanthricin
Isoanthricin ((Rac)-Deoxypodophyllotoxin) is the racemate of Deoxypodophyllotoxin. Deoxypodophyllotoxin is a potent antitumor and anti-inflammatory agent.
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- CAS 番号: 69222-20-4
- 分子式: C22H22O7
- 分子量:398.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 69222-20-4
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分子量 398.41
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分子式 C22H22O7
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SMILES
COC1=C(OC)C(OC)=CC(C(C(C(OC2)=O)C2C3)C4=C3C=C(OCO5)C5=C4)=C1
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別名
(Rac)-Deoxypodophyllotoxin
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
純度とドキュメンテーション
参考文献
[1]. Khaled M, et, al. Deoxypodophyllotoxin: a promising therapeutic agent from herbal medicine. J Ethnopharmacol. 2013 Aug 26;149(1):24-34. [Content Brief]
[2]. Kozawa M, et, al. [Chemical components of the roots of Anthriscus sylvestris Hoffm. I. Structures of an acyloxycarboxylic acid and a new phenylpropanoidester, anthriscusin (author's transl)]. Yakugaku Zasshi. 1978 Nov;98(11):1486-90. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isoanthricin 関連分類
HY-N8038 関連分類
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