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Zigakibart

(Synonyms: BION-1301)
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Based on 1 Customer Validation

Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity.

For research use only. We do not sell to patients.

  • Purity: 99.30%
  • CAS No.: 2642175-46-8
  • Molecular Weight:145.04 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Zigakibart
  • Experimental Validation Results for Zigakibart
  • Experimental Validation Results for Zigakibart
  • Zigakibart Chemical Structure
    Zigakibart Chemical Structure
CAS No.: 2642175-46-8
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All TNF Receptor Isoforms

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100 mg

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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized APRIL/TNFSF13 Trimer Protein, Human (HEK293, Flag-His, HY-P70733) can bind Zigakibart. The EC50 for this effect is 7.098 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 1µg/mL LPS for 24h with Zigakibart (HY-P990070, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control，cells without incubation with primary antibody were used as the unlabeled control (black).

  • Zigakibart Chemical Structure
    1/16
  • Zigakibart
  • Immobilized APRIL/TNFSF13 Trimer Protein, Human (HEK293, Flag-His, HY-P70733) can bind Zigakibart. The EC50 for this effect is 7.098 ng/mL.
  • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 1µg/mL LPS for 24h with Zigakibart (HY-P990070, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control，cells without incubation with primary antibody were used as the unlabeled control (black).