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  3. Oenothein B

Oenothein B 

Cat. No.: HY-N7765
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Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.

For research use only. We do not sell to patients.

Oenothein B Chemical Structure

Oenothein B Chemical Structure

CAS No. : 104987-36-2

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Description

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].

In Vitro

Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1].
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1].
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1].
A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours
Result: Effectively inhibited the proliferation of A549 cells.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Induced apoptosis in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Arrested cells in the G1 phase.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
In Vivo

Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1571.10

Formula

C₆₈H₅₀O₄₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Oenothein B
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