Oenothein B
Based on 1 Customer Validation
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.38%
- CAS. Nr.: 104987-36-2
- Formel: C68H48O44
- Molecular Weight:1569.08
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Chemical Information
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Biologische Aktivität
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1].
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1].
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1].
A549 cells[1]
15 µM, 30 µM and 45 µM
24 hours
Arrested cells in the G1 phase.
A549 cells[1]
15 µM, 30 µM and 45 µM
24 hours
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:15 µM, 30 µM and 45 µM
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Incubation Time:12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours
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Result:Effectively inhibited the proliferation of A549 cells.
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Cell Line:A549 cells
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Concentration:15 µM, 30 µM and 45 µM
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Incubation Time:24 hours
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Result:Induced apoptosis in A549 cells.
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Cell Line:A549 cells
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Concentration:15 µM, 30 µM and 45 µM
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Incubation Time:24 hours
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Result:Arrested cells in the G1 phase.
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Cell Line:A549 cells
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Concentration:15 µM, 30 µM and 45 µM
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Incubation Time:24 hours
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Result:BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 104987-36-2
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Appearance Solid
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Molecular Weight 1569.08
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Formel C68H48O44
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Color White to light yellow
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SMILES
O=C1C2=CC(OC3=C(C4=O)C=C(O)C(O)=C3O)=C(O)C(O)=C2C5=C(C(OC[C@@H](O[C@@H](O)[C@H](OC(C6=C(OC7=C(O)C(O)=C(C8=C9C=C(O)C(O)=C8O)C(C(OC[C@H]%10O[C@@H](O)[C@H](O4)[C@@H](OC(C%11=CC(O)=C(O)C(O)=C%11)=O)[C@@H]%10OC9=O)=O)=C7)C(O)=C(O)C(O)=C6)=O)[C@H]%12OC(C%13=CC(O)=C(O)C(O)=C%13)=O)[C@H]%12O1)=O)C=C(O)C(O)=C5O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (79.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (290 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120. [Content Brief]
[2]. Satoru Tamura, et al. Oenothein B, dimeric hydrolysable tannin inhibiting HCV invasion from Oenothera erythrosepala. J Nat Med. 2019 Jan;73(1):67-75. [Content Brief]
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6373 mL | 3.1866 mL | 6.3732 mL | 15.9329 mL |
| 5 mM | 0.1275 mL | 0.6373 mL | 1.2746 mL | 3.1866 mL | |
| 10 mM | 0.0637 mL | 0.3187 mL | 0.6373 mL | 1.5933 mL | |
| 15 mM | 0.0425 mL | 0.2124 mL | 0.4249 mL | 1.0622 mL | |
| 20 mM | 0.0319 mL | 0.1593 mL | 0.3187 mL | 0.7966 mL | |
| 25 mM | 0.0255 mL | 0.1275 mL | 0.2549 mL | 0.6373 mL | |
| 30 mM | 0.0212 mL | 0.1062 mL | 0.2124 mL | 0.5311 mL | |
| 40 mM | 0.0159 mL | 0.0797 mL | 0.1593 mL | 0.3983 mL | |
| 50 mM | 0.0127 mL | 0.0637 mL | 0.1275 mL | 0.3187 mL | |
| 60 mM | 0.0106 mL | 0.0531 mL | 0.1062 mL | 0.2655 mL |
Oenothein B Related Classifications
HY-N7765 Related Classifications
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