2. Anti-infection Apoptosis
  3. HCV Bacterial Apoptosis Fungal
  4. Oenothein B

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase.

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Oenothein B Chemical Structure

Oenothein B Chemical Structure

CAS No. : 104987-36-2

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Based on 1 publication(s) in Google Scholar

Oenothein B Related Antibodies

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Description

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].

In Vitro

Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1].
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1].
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1].
A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oenothein B Related Antibodies

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours
Result: Effectively inhibited the proliferation of A549 cells.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Induced apoptosis in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Arrested cells in the G1 phase.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
In Vivo

Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1569.08

Formula

C68H48O44
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C2=CC(OC3=C(C4=O)C=C(O)C(O)=C3O)=C(O)C(O)=C2C5=C(C(OC[C@@H](O[C@@H](O)[C@H](OC(C6=C(OC7=C(O)C(O)=C(C8=C9C=C(O)C(O)=C8O)C(C(OC[C@H]%10O[C@@H](O)[C@H](O4)[C@@H](OC(C%11=CC(O)=C(O)C(O)=C%11)=O)[C@@H]%10OC9=O)=O)=C7)C(O)=C(O)C(O)=C6)=O)[C@H]%12OC(C%13=CC(O)=C(O)C(O)=C%13)=O)[C@H]%12O1)=O)C=C(O)C(O)=C5O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (79.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6373 mL 3.1866 mL 6.3732 mL
5 mM 0.1275 mL 0.6373 mL 1.2746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6373 mL 3.1866 mL 6.3732 mL 15.9329 mL
5 mM 0.1275 mL 0.6373 mL 1.2746 mL 3.1866 mL
10 mM 0.0637 mL 0.3187 mL 0.6373 mL 1.5933 mL
15 mM 0.0425 mL 0.2124 mL 0.4249 mL 1.0622 mL
20 mM 0.0319 mL 0.1593 mL 0.3187 mL 0.7966 mL
25 mM 0.0255 mL 0.1275 mL 0.2549 mL 0.6373 mL
30 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5311 mL
40 mM 0.0159 mL 0.0797 mL 0.1593 mL 0.3983 mL
50 mM 0.0127 mL 0.0637 mL 0.1275 mL 0.3187 mL
60 mM 0.0106 mL 0.0531 mL 0.1062 mL 0.2655 mL
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Oenothein B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oenothein B104987-36-2HCVBacterialApoptosisFungalHepatitis C virusmacrocyclicellagitanninantioxidantanti-inflammatoryantifungalanti-HCVantitumorpoly(ADP-ribose)glycohydrolaseInhibitorinhibitorinhibit

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