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  3. BMS-587101

BMS-587101 

Cat. No.: HY-120628
Handling Instructions

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.

For research use only. We do not sell to patients.

BMS-587101 Chemical Structure

BMS-587101 Chemical Structure

CAS No. : 509083-77-6

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Description

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research[1][2].

In Vitro

BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production[1][2].
In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC50 of 150 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

555.43

Formula

C₂₆H₂₀Cl₂N₄O₄S

CAS No.
SMILES

O=C(C1=CSC(CN(C[[email protected]]2C3=CC=C(C#N)C=C3)C[[email protected]]2(N(C)C(N4C5=CC(Cl)=CC(Cl)=C5)=O)C4=O)=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BMS-587101BMS587101BMS 587101IntegrinLFA-1anti-inflammatoryβ2-integrinTh1T-cellInhibitorinhibitorinhibit

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HY-120628
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