509083-77-6
509083-77-6
Chemical Structure
BMS-587101
- CAS No.: 509083-77-6
- Formula:C26H20Cl2N4O4S
- Molecular Weight:555.43
IUPAC Name: 5-(((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)methyl)thiophene-3-carboxylic acid
InChIKey: NXNKJLOEGWSJGI-BKMJKUGQSA-N
SMILES: O=C(C1=CSC(CN(C[C@H]2C3=CC=C(C#N)C=C3)C[C@]2(N(C)C(N4C5=CC(Cl)=CC(Cl)=C5)=O)C4=O)=C1)O
Biological Activity: BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-587101 | 98.81% | BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-10596RBMS-688521 (Standard) -
Similarity Score 0.61
HY-177318αLβ2 integrin-IN-1 -
Similarity Score 0.50
HY-110117BIRT 377 -
Similarity Score 0.49
HY-162432TB114 -
Similarity Score 0.47
HY-100765BI-0252 -
Similarity Score 0.46
HY-118180CAY10595 -
Similarity Score 0.46
HY-163083JN122 -
Similarity Score 0.45
HY-125858MI-1061 -
Similarity Score 0.45
HY-125858B(S,R,S)-MI-1061 -
Explore the MedChemAI to find more analogs
References
- [1]. Dominique Potin, et al. Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function a [Content Brief]
- [2]. Suzanne J Suchard, et al. An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis. J Immunol. 2010 Apr 1;184(7):3917-26. [Content Brief]
