2. Cytoskeleton Immunology/Inflammation
  3. Integrin Interleukin Related
  4. BIRT 377

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders.

For research use only. We do not sell to patients.

BIRT 377 Chemical Structure

BIRT 377 Chemical Structure

CAS No. : 213211-10-0

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Based on 1 publication(s) in Google Scholar

BIRT 377 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), with a Ki of 25.8 nM. BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

IC50 & Target

Ki: 25.8 nM (LFA-1)[1]
Molecular Weight

442.13

Formula

C18H15BrCl2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2618 mL 11.3089 mL 22.6178 mL
5 mM 0.4524 mL 2.2618 mL 4.5236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2618 mL 11.3089 mL 22.6178 mL 56.5445 mL
5 mM 0.4524 mL 2.2618 mL 4.5236 mL 11.3089 mL
10 mM 0.2262 mL 1.1309 mL 2.2618 mL 5.6544 mL
15 mM 0.1508 mL 0.7539 mL 1.5079 mL 3.7696 mL
20 mM 0.1131 mL 0.5654 mL 1.1309 mL 2.8272 mL
25 mM 0.0905 mL 0.4524 mL 0.9047 mL 2.2618 mL
30 mM 0.0754 mL 0.3770 mL 0.7539 mL 1.8848 mL
40 mM 0.0565 mL 0.2827 mL 0.5654 mL 1.4136 mL
50 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1309 mL
60 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9424 mL
80 mM 0.0283 mL 0.1414 mL 0.2827 mL 0.7068 mL
100 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5654 mL
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BIRT 377 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIRT 377213211-10-0BIRT377BIRT-377IntegrinInterleukin RelatedILOrallyLFA-1ICAM-1LymphocyteIL-2Inhibitorinhibitorinhibit

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