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Cat. No.: HY-162432

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TB114

MDM2-IN-27 targets MDM2 protein (K_i = 0.4 nM). MDM2-IN-27 activates the anti-tumor activity of p53 and induces apoptosis by blocking the negative regulation of p53 by MDM2.

For research use only. We do not sell to patients.

CAS No.: 3058605-06-1
Formula: C₃₂H₃₃Cl₂N₃O₄
Molecular Weight:594.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

TB114 Chemical Structure

CAS No.: 3058605-06-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MDM2-IN-27 targets MDM2 protein (K_i = 0.4 nM). MDM2-IN-27 activates the anti-tumor activity of p53 and induces apoptosis by blocking the negative regulation of p53 by MDM2^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	184 nM Compound: 2	Antiproliferative activity against human A549 cells incubated for 4 days by CCK8 assay Antiproliferative activity against human A549 cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
HCT-116	IC₅₀	28.1 nM Compound: 2	Antiproliferative activity against human HCT-116 cells incubated for 4 days by CCK8 assay Antiproliferative activity against human HCT-116 cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
HEK293	IC₅₀	9.65 μM Compound: 2	Antiproliferative activity against HEK293 cells incubated for 4 days by CCK8 assay Antiproliferative activity against HEK293 cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
HeLa	IC₅₀	12.35 μM Compound: 2	Antiproliferative activity against human HeLa cells incubated for 4 days by CCK8 assay Antiproliferative activity against human HeLa cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
MOLM-13	IC₅₀	0.8 nM Compound: 2	Antiproliferative activity against human MOLM-13 cells incubated for 2 days by CCK8 assay Antiproliferative activity against human MOLM-13 cells incubated for 2 days by CCK8 assay	[PMID: 38581730]
MSTO-211H	IC₅₀	73.4 nM Compound: 2	Antiproliferative activity against human MSTO-211H cells incubated for 4 days by CCK8 assay Antiproliferative activity against human MSTO-211H cells incubated for 4 days by CCK8 assay	[PMID: 38581730]
SW480	IC₅₀	5.94 μM Compound: 2	Antiproliferative activity against human SW480 cells incubated for 4 days by CCK8 assay Antiproliferative activity against human SW480 cells incubated for 4 days by CCK8 assay	[PMID: 38581730]

Chemical Information

CAS No. 3058605-06-1
Molecular Weight 594.53
Formula C₃₂H₃₃Cl₂N₃O₄
SMILES

ClC1=CC([C@@H]2[C@@]3(C4=CC=C(Cl)C=C4NC3)[C@H](CC(C)(C)C)N5[C@H]2C(N(C5)C6=C(OC)C=C(C(O)=O)C=C6)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin Z, et al. Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction. Eur J Med Chem. 2024 Apr 15;270:116366. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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