1. GPCR/G Protein
  2. Prostaglandin Receptor

CAY10595 

Cat. No.: HY-118180
Handling Instructions

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

For research use only. We do not sell to patients.

CAY10595 Chemical Structure

CAY10595 Chemical Structure

CAS No. : 916047-16-0

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

IC50 & Target[1]

CRTH2/DP2 Receptor

10 nM (Ki)

In Vitro

CAY10595 (compound 71) is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM[1].

In Vivo

Administration of the DP2 antagonist CAY10595 slightly delays the development of CIA. Treatment with CAY10595 reduces IgG2a anti-CII levels without modification of IgG anti-CII levels[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2162 mL 11.0808 mL 22.1616 mL
5 mM 0.4432 mL 2.2162 mL 4.4323 mL
10 mM 0.2216 mL 1.1081 mL 2.2162 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

451.23

Formula

C₂₀H₁₃Cl₂FN₂O₅

CAS No.

916047-16-0

SMILES

ClC1=CC=C(C2=C1)N(C(C32CC(N(C3=O)CC4=C(C=CC(Cl)=C4)F)=O)=O)CC(O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
CAY10595
Cat. No.:
HY-118180
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CAY10595

Cat. No.: HY-118180