Cat. No.: HY-30235A

Benzydamine hydrochloride

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Benzydamine hydrochloride is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine hydrochloride can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells.

For research use only. We do not sell to patients.

Purity: 99.21%
CAS No.: 132-69-4
Formula: C₁₉H₂₄ClN₃O
Molecular Weight:345.87

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Benzydamine hydrochloride Chemical Structure

CAS No.: 132-69-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TNF Receptor Isoforms :

In Vitro

Benzydamine hydrochloride has a MIC of 0.5 mg/mL and a MLC of 1.0 mg/mL against Escherichia coli, ATCC 8739, and a MIC of 1.0 mg/mL and a MLC of 1.0 mg/mL against Proteus vulgaris, ATCC 13315^[1].
Benzydamine (1.0 mg/mL, 24 h) hydrochloride inhibits the proliferation of Ps. Aeruginosa^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Ps. aeruginosa
Concentration:

1.0 mg/mL
Incubation Time:

24 h
Result:

Inhibited the proliferation of Ps. aeruginosa.

Chemical Information

CAS No. 132-69-4
Appearance Solid
Molecular Weight 345.87
Formula C₁₉H₂₄ClN₃O
Color White to off-white
SMILES

CN(C)CCCOC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 41 mg/mL (118.54 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8913 mL

14.4563 mL

28.9126 mL

5 mM

0.5783 mL

2.8913 mL

5.7825 mL

10 mM

0.2891 mL

1.4456 mL

2.8913 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (289.13 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fanaki NH, et al. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52. [Content Brief]

[2]. Quane PA, Pharmacology of benzydamine. Inflammopharmacology. 1998;6(2):95-107 [Content Brief]

[3]. R S Turnbull, et al. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. J Can Dent Assoc. 1995 Feb;61(2):127-34. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.8913 mL	14.4563 mL	28.9126 mL	72.2815 mL
	5 mM	0.5783 mL	2.8913 mL	5.7825 mL	14.4563 mL
	10 mM	0.2891 mL	1.4456 mL	2.8913 mL	7.2281 mL
	15 mM	0.1928 mL	0.9638 mL	1.9275 mL	4.8188 mL
	20 mM	0.1446 mL	0.7228 mL	1.4456 mL	3.6141 mL
	25 mM	0.1157 mL	0.5783 mL	1.1565 mL	2.8913 mL
	30 mM	0.0964 mL	0.4819 mL	0.9638 mL	2.4094 mL
	40 mM	0.0723 mL	0.3614 mL	0.7228 mL	1.8070 mL
	50 mM	0.0578 mL	0.2891 mL	0.5783 mL	1.4456 mL
	60 mM	0.0482 mL	0.2409 mL	0.4819 mL	1.2047 mL
	80 mM	0.0361 mL	0.1807 mL	0.3614 mL	0.9035 mL
	100 mM	0.0289 mL	0.1446 mL	0.2891 mL	0.7228 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Benzydamine hydrochloride

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All TNF Receptor Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Benzydamine hydrochloride Related Classifications

HY-30235A Related Classifications