1. Immunology/Inflammation
  2. COX
  3. Flosulide

Flosulide (Synonyms: ZK 38997; CGP 28238)

Cat. No.: HY-U00083
Handling Instructions

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

For research use only. We do not sell to patients.

Flosulide Chemical Structure

Flosulide Chemical Structure

CAS No. : 80937-31-1

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Description

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

IC50 & Target

COX-2

 

In Vitro

Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged[2].

In Vivo

In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].

Molecular Weight

353.34

Formula

C₁₆H₁₃F₂NO₄S

CAS No.

80937-31-1

SMILES

CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1OC3=CC=C(F)C=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[2]

The proliferation of the esophageal tumor cell lines is determined using the cell proliferation kit II. Tumor cells are incubated with flosulide and NS-398 at different concentrations for 48 h in DMEM containing FCS (10%), penicillin (100 units/mL), and streptomycin (0.1 mg/mL). After this time, the XTT labeling mixture is added, followed by 4 h of incubation and measurement of absorbance at 490 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

FlosulideZK 38997CGP 28238ZK38997ZK-38997CGP28238CGP-28238COXCyclooxygenaseInhibitorinhibitorinhibit

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