1. Immunology/Inflammation
  2. COX
  3. Flosulide

Flosulide (Synonyms: ZK 38997; CGP 28238)

Cat. No.: HY-U00083
Handling Instructions

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

For research use only. We do not sell to patients.

Flosulide Chemical Structure

Flosulide Chemical Structure

CAS No. : 80937-31-1

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Description

Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.

IC50 & Target

COX-2

 

In Vitro

Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.34

Formula

C₁₆H₁₃F₂NO₄S

CAS No.
SMILES

CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1OC3=CC=C(F)C=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[2]

The proliferation of the esophageal tumor cell lines is determined using the cell proliferation kit II. Tumor cells are incubated with flosulide and NS-398 at different concentrations for 48 h in DMEM containing FCS (10%), penicillin (100 units/mL), and streptomycin (0.1 mg/mL). After this time, the XTT labeling mixture is added, followed by 4 h of incubation and measurement of absorbance at 490 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

FlosulideZK 38997 CGP 28238ZK38997ZK-38997CGP28238CGP 28238CGP-28238COXCyclooxygenaseInhibitorinhibitorinhibit

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