1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. VAF347

VAF347 

Cat. No.: HY-135750
Handling Instructions

VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.

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VAF347 Chemical Structure

VAF347 Chemical Structure

CAS No. : 574759-62-9

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Description

VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects[1].

IC50 & Target

Aryl hydrocarbon receptor[1]

In Vitro

VAF347 (0.01-20 μM; 48-72 hours; HL-60 cells) treatment enhances retinoic acid-induced cell cycle arrest[1].
VAF347 (20 μM; 48 hours; HL-60 cells) treatment augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of partners in the signalsome appear to be enhanced: Fgr interaction with c-Cbl, CD38, and with pS259c-Raf and AhR interaction with c-Cbl and Lyn[1].

Cell Cycle Analysis[1]

Cell Line: HL-60 cells
Concentration: 10 nM, 100 nM, 1 μM, 10 μM, 20 μM
Incubation Time: 48 hours or 72 hours
Result: Enhanced retinoic acid-induced cell cycle arrest in G1/0.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox.
Molecular Weight

349.74

Formula

C₁₇H₁₁ClF₃N₃

CAS No.

574759-62-9

SMILES

FC(C1=CC=C(NC2=NC=CC(C3=CC=CC(Cl)=C3)=N2)C=C1)(F)F

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VAF347VAF 347VAF-347Aryl Hydrocarbon ReceptorAhRCellcyclearrestLynVav1c-Cblanti-inflammatorygranulo-monocyticmonocytesInhibitorinhibitorinhibit

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VAF347
Cat. No.:
HY-135750
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