GW 848687X
GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.
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- CAS. Nr.: 612831-24-0
- Formel: C24H18ClF2NO3
- Molecular Weight:441.85
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FCA induced joint pain model of inflammatory pain[1]
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Dosage:30mg/kg
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Administration:po; twice daily for 5 days
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Result:Completely reversed pain sensation in rats and had anti-pain effects.
Chemical Information
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CAS. Nr. 612831-24-0
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Molecular Weight 441.85
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Formel C24H18ClF2NO3
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SMILES
O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GW 848687X Related Classifications
HY-14466 Related Classifications
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