2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. GW 848687X

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.

For research use only. We do not sell to patients.

GW 848687X Chemical Structure

GW 848687X Chemical Structure

CAS No. : 612831-24-0

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Description

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1].

In Vivo

GW 848687X (30 mg/kg; po; b.i.d, 5 d) exhibits antihyperalgesic activity in an FCA-induced inflammatory joint pain model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FCA induced joint pain model of inflammatory pain[1]
Dosage: 30mg/kg
Administration: po; twice daily for 5 days
Result: Completely reversed pain sensation in rats and had anti-pain effects.
Molecular Weight

441.85

Formula

C24H18ClF2NO3
CAS No.
SMILES

O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 848687X612831-24-0Prostaglandin ReceptorInhibitorinhibitorinhibit

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