GW 848687X
GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain.
For research use only. We do not sell to patients.
- CAS No.: 612831-24-0
- Formula: C24H18ClF2NO3
- Molecular Weight:441.85
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:FCA induced joint pain model of inflammatory pain[1]
-
Dosage:30mg/kg
-
Administration:po; twice daily for 5 days
-
Result:Completely reversed pain sensation in rats and had anti-pain effects.
Chemical Information
-
CAS No. 612831-24-0
-
Molecular Weight 441.85
-
Formula C24H18ClF2NO3
-
SMILES
O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW 848687X Related Classifications
HY-14466 Related Classifications
Powered by Bioz