612831-24-0
612831-24-0
Chemical Structure
GW 848687X
- CAS No.: 612831-24-0
- Formula:C24H18ClF2NO3
- Molecular Weight:441.85
IUPAC Name: 6-(2-(5-chloro-2-((2,4-difluorobenzyl)oxy)phenyl)cyclopent-1-en-1-yl)picolinic acid
InChIKey: PFODPHDNBFSMOX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O
Biological Activity: GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1].
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GW 848687X | GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain. | |||||||||||||||||||||
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References
- [1]. Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. [Content Brief]
