Crocin-4
Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities.
For research use only. We do not sell to patients.
- CAS No.: 55750-86-2
- Formula: C27H36O9
- Molecular Weight:504.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Crocin-4 (0.1-1000 μM; 24-72 h) do not compromise cell viability of neuron-like cells[1].
Crocin-4 (1 mM; 72 h) reduces total PSEN1, PSEN1 and PSEN2 complexes, BACE1, APP-C99 and sAPPα, while it increases PSEN1-CTF and PSEN2 in SH-SY5Y-APP cells[1].
Crocin-4 (1 mM; 72 h) suppresses GSK3β and ERK1/2 kinases in PC12-htau cells, and significantly reduces the levels and phosphorylation of tau on the pThr231 and pSer199/Ser202 epitopes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Differentiated SH-SY5Y-APP cells
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Concentration:1 mM
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Incubation Time:72 hours
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Result:Significantly reduced total PSEN1 by 19%, and the PSEN1 and PSEN2 complexes by 81 and 65%, while it increased PSEN1-CTF (26%) and PSEN2 (43%).
The key molecules of the amyloidogenic pathway, BACE1 and APP-C99 were significantly reduced by 20 and 28%, respectively.
The non-amyloidogenic pathway product sAPPα was also reduced, by 44%, while APP-C83 remained unaltered.
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Cell Line:Differentiated PC12-htau cells
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Concentration:1 mM
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Incubation Time:72 hours
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Result:Significantly reduced total tau levels (by 32%) and tau phosphorylation (pThr231 and pSer199/Ser202-tau by 22 and 75%, respectively).
Downregulates the active and inactive forms of GSK3β (total GSK3β by 34%, pSer9-GSK3β by 30%) and ERK1/2 (total ERK2 by 37%, pERK1 by 40%, pERK2 by 50%).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 55750-86-2
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Molecular Weight 504.57
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Formula C27H36O9
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SMILES
COC(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chalatsa I, et, al. The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models. Front Neurosci. 2019 Mar 26;13:249. [Content Brief]
[2]. Koulakiotis NS, et, al. Crocus-derived compounds alter the aggregation pathway of Alzheimer's Disease: associated beta amyloid protein. Sci Rep. 2020 Oct 23;10(1):18150. [Content Brief]
[3]. Karkoula E, et, al. Trans-crocin 4 is not hydrolyzed to crocetin following i.p. administration in mice, while it shows penetration through the blood brain barrier. Fitoterapia. 2018 Sep;129:62-72. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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