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Polzastobart

(Synonyms: JTX 8064)
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Based on 1 Customer Validation

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor.

For research use only. We do not sell to patients.

  • Purity: 97.81%
  • CAS No.: 2640981-19-5
  • Molecular Weight:146.48 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Polzastobart
  • Experimental Validation Results for Polzastobart
  • Experimental Validation Results for Polzastobart
  • Polzastobart Chemical Structure
    Polzastobart Chemical Structure
CAS No.: 2640981-19-5
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Polzastobart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow cytometric analysis of 1X106 THP-1 cells with Polzastobart (HY-P990061, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized LILRB2/CD85d/ILT-4 Protein, Human can bind Polzastobart. The EC50 for this effect is 8.336 ng/mL.

  • Polzastobart Chemical Structure
    1/16
  • Polzastobart
  • Flow cytometric analysis of 1X106 THP-1 cells with Polzastobart (HY-P990061, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized LILRB2/CD85d/ILT-4 Protein, Human can bind Polzastobart. The EC50 for this effect is 8.336 ng/mL.