2. Gene
  3. LILRB2 - leukocyte immunoglobulin like receptor B2 Gene

LILRB2 - leukocyte immunoglobulin like receptor B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10

Gene ID: 10288 | Gene type: protein coding

About LILRB2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,273,812-54,281,110 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 334 orthologues and 25 paralogues. Biased expression in appendix (RPKM 54.6), bone marrow (RPKM 26.2) and 5 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB2 Products(6)

mRNA Protein Name
NM_001080978.4 NP_001074447.2 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 2 precursor
NM_001278403.3 NP_001265332.2 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 2 precursor
NM_001278404.3 NP_001265333.2 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 3
NM_001278405.2 NP_001265334.2 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 4 precursor
NM_001278406.2 NP_001265335.2 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 5 precursor
NM_005874.5 NP_005865.3 leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 1 precursor

LILRB2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 113)

Ig_3

Ig_3: Immunoglobulin domain (123 - 196)

Ig_2

Ig_2: Immunoglobulin domain (224 - 315)

Ig_3

Ig_3: Immunoglobulin domain (325 - 399)

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  • 598 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 2

CD85 antigen-like family member D

Recombinant LILRB2 Proteins

Cat. No. Product Name Accession Purity
HY-P70168 LILRB2/CD85d/ILT-4 Protein, Human (HEK293, His) AAH36827.1 (Q22-H458) ≥95%
HY-P72396 LILRB2/CD85d/ILT-4 Protein, Human (Biotinylated, HEK293, Avi-His) Q8N423 (Q22-H458) ≥95%
HY-P78478 LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) Q8N423 (Q22-H458) ≥95%
HY-P78483 LILRB2/CD85d/ILT-4 Protein, Human (HEK293, His-Avi) Q8N423 (Q22-H458) ≥95%
HY-P78841 LILRB2/CD85d/ILT-4 Protein, Human (Biotinylated, HEK293, Fc-Avi) AAH36827 (Q22-V461) ≥95%

Related Diseases

Diseases Alias
Hymenolepiasis

Dwarf Tapeworm Infection

Hymenolepis Infectious Disease

Hymenolepsis Infection

Hyemolepis Nana Infection

Hymenolepiosis

Hymenolepis Infection

Dwarf Tapeworm

Hymenolepidosis

Hymenolepis Infestation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07652 LILRB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LILRB2 MGD MGI:894311
Rattus norvegicus LILRB2 RGD RGD:70895
Macaca fascicularis LILRB2 NCBI