LILRB2 - leukocyte immunoglobulin like receptor B2 Gene

Also Known as ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10288

About LILRB2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,273,812-54,281,110 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 334 orthologues and 25 paralogues. Biased expression in appendix (RPKM 54.6), bone marrow (RPKM 26.2) and 5 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB2 Products (6)

mRNA	Protein	Name
NM_001080978.4	NP_001074447.2	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 2 precursor
NM_001278403.3	NP_001265332.2	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 2 precursor
NM_001278404.3	NP_001265333.2	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 3
NM_001278405.2	NP_001265334.2	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 4 precursor
NM_001278406.2	NP_001265335.2	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 5 precursor
NM_005874.5	NP_005865.3	leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	9842885	GOA
enables MHC class I protein binding	IPI IPI: Inferred from physical interaction	19124746	GOA
enables MHC class Ib protein binding	IDA IDA: Inferred from direct assay	11169396	GOA
enables MHC class Ib protein binding	IPI IPI: Inferred from physical interaction	20008523	GOA
enables MHC class Ib protein complex binding	IDA IDA: Inferred from direct assay	17056715	GOA
enables amyloid-beta binding	IMP IMP: Inferred from mutant phenotype	24052308	GOA
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	19124746	GOA
enables inhibitory MHC class I receptor activity	IDA IDA: Inferred from direct assay	20702625	GOA
enables inhibitory MHC class I receptor activity	IMP IMP: Inferred from mutant phenotype	14971032	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11169396	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	24052308	GOA
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9842885	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	24052308	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc receptor mediated inhibitory signaling pathway	IDA IDA: Inferred from direct assay	9842885	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14971032	GOA
involved in heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	19124746	GOA
involved in immune response-inhibiting cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	20702625	GOA
involved in immune response-inhibiting cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14971032	GOA
involved in interleukin-10-mediated signaling pathway	IEP IEP: Inferred from expression pattern	17163451	GOA
involved in negative regulation of T cell costimulation	IMP IMP: Inferred from mutant phenotype	17163451	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19124746	GOA
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	14971032	GOA
involved in negative regulation of antigen processing and presentation	IDA IDA: Inferred from direct assay	19124746	GOA
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	9842885	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	14971032	GOA
involved in positive regulation of T cell tolerance induction	IMP IMP: Inferred from mutant phenotype	20008523	GOA
involved in positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	20448110	GOA
involved in positive regulation of tolerance induction	IMP IMP: Inferred from mutant phenotype	22802125	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	20702625	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	20008523	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	14971032	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19124746	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14971032	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB2 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
100
200
300
400
500
598 a.a.

Protein Preferred Names	Protein Names
leukocyte immunoglobulin-like receptor subfamily B member 2	CD85 antigen-like family member D

Recombinant LILRB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70168	LILRB2/CD85d/ILT-4 Protein, Human (HEK293, His)	AAH36827.1 (Q22-H458)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72396	LILRB2/CD85d/ILT-4 Protein, Human (Biotinylated, HEK293, Avi-His)	AAH36827.1 (Q22-H458)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78478	LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc)	Q8N423 (Q22-H458)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78483	LILRB2/CD85d/ILT-4 Protein, Human (HEK293, His-Avi)	Q8N423 (Q22-H458)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78841	LILRB2/CD85d/ILT-4 Protein, Human (Biotinylated, HEK293, Fc-Avi)	AAH36827 (Q22-V461)	≥ 90%, as determined by reducing SDS-PAGE.

LILRB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84671	LILRB2 Antibody (YA4368)	WB, FC, ELISA	Human
HY-P84671A	LILRB2 Antibody (YA4368)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hymenolepiasis	Dwarf Tapeworm Infection Hymenolepis Infectious Disease Hymenolepsis Infection Hyemolepis Nana Infection Hymenolepiosis Hymenolepis Infection Dwarf Tapeworm Hymenolepidosis Hymenolepis Infestation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990061	Polzastobart	Inhibitor	97.81%	Phase 2

Pre-clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992388	IO-108	Inhibitor	/	Unkown
HY-P992353	ES009	Antagonist	/	Unkown
HY-P991306	ATG-032	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LILRB2	MGD	MGI:894311
Rattus norvegicus	LILRB2	RGD	RGD:70895