1. Recombinant Proteins
  2. Receptor Proteins
  3. Leukocyte Immunoglobin-like Receptors
  4. ILT-4
  5. LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc)

LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc)

Cat. No.: HY-P78478
Handling Instructions

LILRB2/CD85d/ILT-4 Protein, a receptor for class I MHC antigens, recognizes a broad range of HLA alleles. It crucially down-regulates immune responses, establishing tolerance. Specific recognition of HLA-G, with a self-peptide, leads to type 1 regulatory T cell and myeloid-derived suppressor cell differentiation, essential for maternal-fetal tolerance. LILRB2 competes with CD8A, inhibits FCGR1A-mediated responses, and interacts with PTPN6 when phosphorylated. Direct interactions with peptide-bound HLA-G-B2M and HLA-F-B2M emphasize its immune modulation role. LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) is the recombinant human-derived LILRB2/CD85d/ILT-4 protein, expressed by HEK293, with C-mFc labeled tag. The total length of LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) is 437 a.a., with molecular weight of 80-110 kDa.

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Description

LILRB2/CD85d/ILT-4 Protein, a receptor for class I MHC antigens, recognizes a broad range of HLA alleles. It crucially down-regulates immune responses, establishing tolerance. Specific recognition of HLA-G, with a self-peptide, leads to type 1 regulatory T cell and myeloid-derived suppressor cell differentiation, essential for maternal-fetal tolerance. LILRB2 competes with CD8A, inhibits FCGR1A-mediated responses, and interacts with PTPN6 when phosphorylated. Direct interactions with peptide-bound HLA-G-B2M and HLA-F-B2M emphasize its immune modulation role. LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) is the recombinant human-derived LILRB2/CD85d/ILT-4 protein, expressed by HEK293, with C-mFc labeled tag. The total length of LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) is 437 a.a., with molecular weight of 80-110 kDa.

Background

The LILRB2/CD85d/ILT-4 Protein serves as a receptor for class I MHC antigens, demonstrating recognition across a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G, and HLA-F alleles. It plays a crucial role in immune response down-regulation and the establishment of tolerance. Specifically, it recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide, leading to the differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, crucial for maintaining maternal-fetal tolerance. LILRB2 competes with CD8A for binding to class I MHC antigens and inhibits FCGR1A-mediated cellular responses, including phosphorylation of proteins and mobilization of intracellular calcium ions. Moreover, it interacts with PTPN6 when phosphorylated and binds to FCGR1A. The direct interactions with peptide-bound HLA-G-B2M and HLA-F-B2M further highlight its involvement in immune modulation.

Species

Human

Source

HEK293

Tag

C-mFc

Accession

Q8N423 (Q22-H458)

Gene ID
Molecular Construction
N-term
LILRB2 (Q22-H458)
Accession # Q8N423
mFc
C-term
Synonyms
CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10
Molecular Weight

80-110 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LILRB2/CD85d/ILT-4 Protein, Human (HEK293, mFc)
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HY-P78478
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