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    NF-κB
  3. Gypenoside L

Gypenoside L 

Cat. No.: HY-N8211
Handling Instructions

Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.

For research use only. We do not sell to patients.

Gypenoside L Chemical Structure

Gypenoside L Chemical Structure

CAS No. : 94987-09-4

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Description

Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities[1][2].

In Vitro

Gypenoside L (20-80 μg/mL; 24 h) increases the mRNA expression levels of SASP, such as IL-1α, IL-6, TIMP-1, CXCL-1 and CXCL-2 in HepG2 and ECA-109 cells[1].
Gypenoside L (20-80 μg/mL; 24 h) causes cell cycle arrest at S phase[1].
GPL (3.125-100 μg/mL) significantly inhibits LPS-induced NO accumulation in RAW264.7 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

801.01

Formula

C₄₂H₇₂O₁₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Gypenoside L
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