1. MAPK/ERK Pathway
    NF-κB
  2. p38 MAPK
    NF-κB
  3. Cornuside

Cornuside 

Cat. No.: HY-N0631
Handling Instructions

Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases.

For research use only. We do not sell to patients.

Cornuside Chemical Structure

Cornuside Chemical Structure

CAS No. : 131189-57-6

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Description

Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1].

IC50 & Target[1]

p38 MAP kinase

 

NF-κB

 

Molecular Weight

542.49

Formula

C₂₄H₃₀O₁₄

CAS No.

131189-57-6

SMILES

O=C(C1=CC(O)=C(O)C(O)=C1)OCCC(C(C(OC)=O)=COC2OC(C(C(O)C3O)O)OC3CO)C2C=C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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