CAT

By Targets:	5-HT Receptor (2) Adrenergic Receptor (3) Akt (3) AMPK (3) Amyloid-β (1) Angiotensin Receptor (2) Antibiotic (11) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (15) Arrestin (2) Autophagy (9) Bacterial (22) Bcl-2 Family (1) Biochemical Assay Reagents (17) Calcium Channel (6) Calmodulin (2) Cathepsin (7) CCR (1) CD22 (1) CGRP Receptor (5) Chloride Channel (3) Cholecystokinin Receptor (3) Cholinesterase (ChE) (1) COX (5) DNA/RNA Synthesis (1) Dopamine Transporter (1) Drug Metabolite (1) Endogenous Metabolite (5) Epigenetic Reader Domain (2) ERK (4) Ferroptosis (1) Fluorescent Dye (3) Fungal (6) GABA Receptor (1) GPR119 (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (1) HSV (1) iGluR (2) Influenza Virus (1) Insulin Receptor (1) Integrin (1) Isotope-Labeled Compounds (6) mAChR (1) mGluR (2) Mitochondrial Metabolism (5) Monoamine Transporter (1) Mps1 (1) Na+/H+ Exchanger (NHE) (2) Na+/K+ ATPase (1) NF-κB (2) Oxidative Phosphorylation (5) Parasite (6) Phosphatase (3) Phosphodiesterase (PDE) (2) Piezo Channel (2) PKC (4) Potassium Channel (5) Prostaglandin Receptor (3) Ras (1) Reactive Oxygen Species (3) SARS-CoV (1) Serotonin Transporter (1) Small Interfering RNA (siRNA) (1) SOD (5) TGF-beta/Smad (2) TGF-β Receptor (1) Toll-like Receptor (TLR) (2) TRP Channel (18) Urotensin Receptor (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (24) Endocrinology (5) Infection (22) Inflammation/Immunology (30) Metabolic Disease (10) Neurological Disease (34)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17630

Edasalonexent

CAT-1004
NF-κB Metabolic Disease

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

Edasalonexent CAT-1004	NF-κB	Metabolic Disease
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

HY-P99305

Metelimumab CAT-192; Anti-TGFB1 Recombinant Antibody	TGF-β Receptor	Inflammation/Immunology
Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1 .

HY-P99695

Lerdelimumab CAT-152	TGF-beta/Smad	Neurological Disease
Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research .

HY-P99474

Bertilimumab CAT 213; iCo-008	CCR	Inflammation/Immunology
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .

HY-RS01982

CAT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAT Human Pre-designed siRNA Set A contains three designed siRNAs for CAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAT Human Pre-designed siRNA Set A CAT Human Pre-designed siRNA Set A

HY-P99255

Moxetumomab pasudotox CAT 8015; HA 22; Anti-Human CD22 Recombinant Antibody	Antibody-Drug Conjugates (ADCs) CD22	Cancer
Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 F_v and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL) .

HY-146581

Cathepsin C-IN-4	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-4 (compound SF27) is a potent *Cathepsin C (Cat* C) inhibitor, with an IC₅₀ of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC₅₀** values of 203.4 and 177.6 nM, respectively .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-100231

Cathepsin inhibitor 1
Cathepsin inhibitor 1 (compound 25) is a potent and selective inhibitor of Cathepsin, with pIC₅₀s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, *CatS, CatK, and CatB*, respectively .

HY-146580

Cathepsin C-IN-3	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-3 (compound SF11) is a potent *Cathepsin C (Cat* C) inhibitor, with an IC₅₀ of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC₅₀** values of 101.5 and 86.5 nM, respectively .

HY-143714

Cathepsin K inhibitor 2	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .

HY-107756

LOE 908 hydrochloride

Calcium Channel Neurological Disease

LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor .

LOE 908 hydrochloride	Calcium Channel	Neurological Disease
LOE 908 hydrochloride is a non-selective cation channel (NSCC) inhibitor .

HY-111525

Monactin	Oxidative Phosphorylation Bacterial Antibiotic	Infection
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-W006212

1,4,7-Triazonane 1,4,7-Triazacyclononane	Biochemical Assay Reagents	Others
1,4,7-Triazonane (1,4,7-Triazacyclononane), an intermediate in the synthesis of 1,4,7-trifunctionalized derivatives, is a possible reagent for compleximetric titrations with high cation-binding selectivity .

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-122605

TRPM4-IN-1 CBA	TRP Channel	Cardiovascular Disease Cancer
TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC₅₀ of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) is an antibiotic and a unique *divalent cation* ionophore** (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique *divalent cation* ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis** .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique *divalent cation* ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis** .

HY-119572

Sodium zirconium cyclosilicate	Others	Inflammation/Immunology
Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K ⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD) .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	PKC TRP Channel Endogenous Metabolite	Neurological Disease
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment *nonselective cation* channel (NSCC)** activity .

HY-10290

MK-0674	Cathepsin	Metabolic Disease
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC₅₀ of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S .

HY-107535

AS1269574	GPR119 TRP Channel	Metabolic Disease
AS1269574 is a potent, orally available GPR119 agonist, with an EC₅₀ of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes .

HY-147333

Trimipramine N-oxide	Drug Metabolite	Neurological Disease
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC₅₀s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety .

HY-157243

CEX Cation-exchange resin 2	Others	Others
CEX Cation-exchange resin 2 is a CEX strong cation exchange resin, ADC purification resin. CEX Cation-exchange resin 2 contains cross-linked poly(styrene-divinylbenzene), which has good hydrophobicity .

HY-D1640

5',5-Difluoro BAPTA tetrapotassium	Biochemical Assay Reagents	Others
5,5'-Difluoro BAPTA tetrapotassium is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA tetrapotassium shows large ¹⁹F NMR chemical shifts upon chelating divalent cations. 5,5'-Difluoro BAPTA tetrapotassium has high selectivity for Ca ²⁺. 5,5'-Difluoro BAPTA tetrapotassium can inhibit the growth of pollen tube .

HY-118874

Oblimersen	Bcl-2 Family Apoptosis	Cancer
Oblimersen is a BCL-2 inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research .

HY-142118

Trabedersen AP 12009	TGF-beta/Smad	Cancer
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

HY-146245

ODN 1826 CpG 1826	Toll-like Receptor (TLR) Apoptosis	Inflammation/Immunology Cancer
ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .

HY-150726

ODN 1668	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’ .

HY-145728

Alicaforsen ISIS-2302	Integrin	Inflammation/Immunology
Alicaforsen is a 20-base antisense oligonucleotide inhibiting ICAM-1 production, which is an important adhesion molecule involved in leukocyte migration and trafficking to the site of inflammation.

HY-153614

Ac-VLPE-FMK Ac-Val-Leu-Pro-Glu(OMe)-CH2F	Cathepsin	Cancer
Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a *Cat-B* and *Cat-L* inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness .

HY-157241

CEX Cation-exchange resin 1	Others	Others
CEX Cation-exchange resin 1 is an ion exchange chromatography resin based on monodisperse polystyrene/divinylbenzene (PS-DVB). The particle size of CEX Cation-exchange resin 1 is 50μm and the ligand is -CH2CH2CH2SO3-. CEX Cation-exchange resin 1 can be used for the separation and purification of antibodies, VLPs, viruses and proteins .

HY-B0193A

Prazosin hydrochloride 5+ Cited Publications	Adrenergic Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively .

HY-P0163

Gramicidin 3 Publications Verification	Bacterial Antibiotic	Infection
Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

HY-110374

NVS-CECR2-1	Epigenetic Reader Domain Apoptosis	Cancer
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC₅₀=47 nM; K_D=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism .

HY-155254

Sodium ionophore VI

Others Others

Sodium ionophore VI is a sodium ionophore that has been employed for developing cation optical sensors .

Sodium ionophore VI	Others	Others
Sodium ionophore VI is a sodium ionophore that has been employed for developing cation optical sensors .

HY-N1378

(E)-Cardamonin 1 Publications Verification (E)-Cardamomin; (E)-Alpinetin chalcone	TRP Channel Apoptosis	Neurological Disease Cancer
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC₅₀ of 454 nM.

HY-14710

AZ3146

4 Publications Verification

Mps1 Cancer

AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.

AZ3146 4 Publications Verification	Mps1	Cancer
AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC₅₀ of 35 nM for Mps1 ^Cat.

HY-107740

Pseudoisocyanine iodide 1,1'-Diethyl-2,2'-cyanine iodide; Decynium 22; Diethylcyanine iodide; Eastman 7851	Dopamine Transporter Monoamine Transporter Serotonin Transporter	Neurological Disease
Pseudoisocyanine (iodide) is a pan inhibitor of monoamine transporters and organic cation transporters with antidepressant-like activity .

HY-17597

Febantel

Parasite Infection

Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.
HY-129096

IDT307

Fluorescent Dye Others

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

Febantel	Parasite	Infection
Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.

IDT307	Fluorescent Dye	Others
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-124514

UC-857993	Ras ERK	Cancer
UC-857993 is a selective SOS1-Ras inhibitor (K_d=14.7 μM, His₆-SOS1_cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs) .

HY-148162

Kayexalate

Others Others

Kayexalate, a cation-exchange resin, is an orally active plasma potassium inhibitor. Kayexalate can be used in the research of hyperkalemia .
HY-157240

CEX Ion-exchange resin

Others Others

CEX Ion-exchange resin is a filler that can be used in cation exchange chromatography (Particle size: 60 μm) .
HY-157242

CEX Polishing resin

Others Others

CEX Polishing resin is an agarose filler that can be used in cation exchange chromatography (The average particle size: 50 μm) .

Kayexalate	Others	Others
Kayexalate, a cation-exchange resin, is an orally active plasma potassium inhibitor. Kayexalate can be used in the research of hyperkalemia .

CEX Ion-exchange resin	Others	Others
CEX Ion-exchange resin is a filler that can be used in cation exchange chromatography (Particle size: 60 μm) .

CEX Polishing resin	Others	Others
CEX Polishing resin is an agarose filler that can be used in cation exchange chromatography (The average particle size: 50 μm) .

HY-W127701

[Bmpip][NTf2] 1-Butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide	Biochemical Assay Reagents	Others
[Bmpip][NTf2] is composed of 1-butyl-1-methylimidazolium cation and bis(trifluoromethylsulfonyl)imide anion.

HY-B1793

Tetraethylammonium chloride 3 Publications Verification	Potassium Channel	Neurological Disease Cancer
Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties .

HY-P2887

Acetate kinase (ACK)	Endogenous Metabolite	Others
Acetate kinase (ACK) is an enzyme widely distributed in bacteria and archaea. In the presence of ATP and divalent cations, it catalyzes the phosphorylation of acetate and promotes the production of acetyl-CoA. Often used in biochemical research .

HY-15533

LY 3000328 5 Publications Verification Z-FL-COCHO	Cathepsin	Inflammation/Immunology
LY 3000328 (Z-FL-COCHO) is a potent and selective *Cathepsin S (Cat* S) inhibitor with IC₅₀**s of 7.7 and 1.67 nM for hCat S and mCat S, respectively.

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1118 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-129096

IDT307

Chromogenic Substrates

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-D0193

Ponceau 4R 1 Publications Verification Acid Red 18; New Coccine	Dyes
Ponceau 4R is a synthetic colorant that can be used for food coloring. Ponceau 4R is a strawberry red azo dye that can be used in a variety of foods, usually synthesized from aromatic hydrocarbons, and is stable to light, heat, and acids .

Cat. No.	Product Name	Type

HY-W127701

[Bmpip][NTf2] 1-Butyl-1-methylpiperidinium bis(trifluoromethylsulfonyl)imide	Biochemical Assay Reagents
[Bmpip][NTf2] is composed of 1-butyl-1-methylimidazolium cation and bis(trifluoromethylsulfonyl)imide anion.

HY-W025784

Kalibor Sodium tetraphenylborate; Tetraphenylboron sodium	Chelators
Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .

HY-P2887

Acetate kinase (ACK)	Biochemical Assay Reagents
Acetate kinase (ACK) is an enzyme widely distributed in bacteria and archaea. In the presence of ATP and divalent cations, it catalyzes the phosphorylation of acetate and promotes the production of acetyl-CoA. Often used in biochemical research .

HY-P2782

Chloramphenicol acetyltransferase CAT	Biochemical Assay Reagents
Chloramphenicol acetyltransferase (CAT) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-157915

HFPB Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate	Chelators
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .

HY-E70191

β-1,4-Galactosyltransferase 2 EC:2.4.1.22; B4GALT2	Enzyme Substrates
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .

HY-156045A

Cross-linked dextran G 10	Filter Medium
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: ＜700 Da) .

HY-125870

Gellan gum	Biochemical Assay Reagents
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .

HY-W011052

Tetrapentylammonium bromide

Biochemical Assay Reagents

Tetrapentylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetrapentylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic synthesis reactions to facilitate the transfer of reactants between immiscible phases. It is also used in the production of surfactants, detergents and the synthesis of pharmaceuticals.

HY-W127739

Zineb Zinc ethylene-1, 2-bisdithiocarbamate	Biochemical Assay Reagents
Zineb is an agricultural fungicide of the dithiocarbamate class. Its toxicity is relatively low, and there is little evidence of human harm from exposure. Oxidative stress is one of the main factors contributing to diseases caused by Zineb. Zineb does not alter the activity of any superoxide dismutase enzymes. Catalase (CAT) activity was reduced only by Zineb.

HY-W075836

Ferrocenylmethyltrimethylammonium iodide

Biochemical Assay Reagents

Ferrocenylmethyltrimethylammonium (iodide) is an organometallic salt consisting of a ferrocenyl group attached to a quaternary ammonium cation via a methylene bridge. Ferrocenylmethyltrimethylammonium (iodide) has been used as a catalyst and reagent in various organic reactions, including oxidation, reduction, and CH bond activation. In addition, it is also used as a precursor for the synthesis of other organometallic compounds and as a potential material for electrochemical applications.

HY-W011087

Benzyldimethyltetradecylammonium chloride

Biochemical Assay Reagents

Benzyldimethyltetradecylammonium chloride is a quaternary ammonium salt consisting of a positively charged N-benzyl-N,N-dimethyltetradecyl-1-amine cation and a negatively charged chloride anion. The compound is commonly used as a surfactant and emulsifier in a variety of applications including detergents, fabric softeners and personal care products. It also has antimicrobial properties and is used as a disinfectant or antiseptic in some products.

HY-W014408

Tetraethylammonium bromide

TEA bromide

Biochemical Assay Reagents

Tetraethylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetraethylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, an electrolyte in electrochemical experiments, and a source of tetraethylammonium ions in biochemical and pharmacological research.

HY-W011972

Bromocholine bromide

Biochemical Assay Reagents

2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.

HY-W013231

N-Benzyl-N,N-diethylethanaminium iodide

Benzyltriethylammonium iodide

Biochemical Assay Reagents

N-Benzyl-N,N-diethylethanaminium iodide is a quaternary ammonium salt consisting of a positively charged N-benzyl-N,N-diethylethylamine cation and a negatively charged iodide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a reagent for the synthesis of various organic compounds, and as a surfactant or emulsifier in industrial and personal care products.

HY-W018574

Tetraoctylammonium bromide

Biochemical Assay Reagents

Tetraoctylammonium bromide (TOAB) is a quaternary ammonium salt consisting of a positively charged tetraoctylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It is also used as a surfactant and dispersant in various industrial applications, for example in the production of coatings, adhesives and polymers. Additionally, Tetraoctylammonium bromide has been investigated for potential applications in energy storage devices and as an antimicrobial agent.

HY-Y0682

Ethylenediaminetetraacetic acid

Maximum Cited Publications

8 Publications Verification

EDTA

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .

HY-W105700

Ethylenediaminetetraacetic acid sodium hydrate

5 Publications Verification

EDTA sodium hydrate

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .

HY-Y0682B

Ethylenediaminetetraacetic acid tetrasodium

5 Publications Verification

EDTA tetrasodium

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research .

HY-Y0682A

Ethylenediaminetetraacetic acid disodium dihydrate

5 Publications Verification

EDTA disodium dihydrate

Biochemical Assay Reagents

Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .

HY-W010736A

1,2-Dipalmitoyl-rac-glycerol

Biochemical Assay Reagents

1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Cat. No.	Product Name	Target	Research Area

HY-P0163

Gramicidin 3 Publications Verification	Bacterial Antibiotic	Infection
Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

HY-P1471

Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-P2782

Chloramphenicol acetyltransferase CAT	Peptides	Others
Chloramphenicol acetyltransferase (CAT) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3711

SPAI-1	Na+/K+ ATPase	Others
SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na ⁺, K ⁺-ATPase and H ⁺, K ⁺-ATPase in vitro, stimulates Mg ²⁺-ATPase .

HY-P5951

Adrenomedullin (1-12) (human)

Peptides Cardiovascular Disease

Adrenomedullin (1-12) (human) is adrenomedullin fragment. Adrenomedullin has no effect on arterial pressure in cats

HY-P1770

Adrenomedullin (16-31), human	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human possesses pressor activity in the systemic vascular bed of the rat, but not the cat .

HY-P1770A

Adrenomedullin (16-31), human TFA	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (16-31), human TFA is amino acid residues 16-31 fragment of human adrenomedullin (hADM). Adrenomedullin has appreciable affinity for the CGRP1 receptor. Adrenomedullin (16-31), human TFA possesses pressor activity in the systemic vascular bed of the rat, but not the cat .

HY-P1471A

Adrenomedullin (AM) (22-52), human TFA 22-52-Adrenomedullin (human) (TFA)	CGRP Receptor	Cardiovascular Disease
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH₂ terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .

HY-P2324

Gramicidin A 1 Publications Verification	Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic	Infection Cancer
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-P2324A

Gramicidin A TFA	Antibiotic Bacterial	Infection
Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .

HY-109556

Insulin Detemir	Akt ERK	Metabolic Disease
Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research .

HY-P1410

GsMTx4 Maximum Cited Publications 28 Publications Verification	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-P1410A

GsMTx4 TFA Maximum Cited Publications 28 Publications Verification	TRP Channel Piezo Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .

HY-P1077

CALP1	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .

HY-P1077A

CALP1 TFA 1 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling . TRV120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the acute decompensated heart failure (ADHF) treatment .

HY-P2141

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling . TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment .

Cat. No.	Product Name	Target	Research Area

HY-P99305

Metelimumab CAT-192; Anti-TGFB1 Recombinant Antibody	TGF-β Receptor	Inflammation/Immunology
Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1 .

HY-P99627

Frunevetmab NV-02	Inhibitory Antibodies	Inflammation/Immunology
Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a K_d of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats .

HY-P99695

Lerdelimumab CAT-152	TGF-beta/Smad	Neurological Disease
Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research .

HY-P99474

Bertilimumab CAT 213; iCo-008	CCR	Inflammation/Immunology
Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .

HY-P99255

Moxetumomab pasudotox CAT 8015; HA 22; Anti-Human CD22 Recombinant Antibody	Antibody-Drug Conjugates (ADCs) CD22	Cancer
Moxetumomab pasudotox (CAT 8015) is anti-CD22 immunotoxin containing an anti-CD22 F_v and Pseudomonas exotoxin. CD22 is a cell surface receptor expressed on a variety of malignant B-cells. Moxetumomab pasudotox can be used in the research of hairy cell leukemia (HCL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique *divalent cation* ionophore** (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	PKC TRP Channel Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment *nonselective cation* channel (NSCC)** activity .

HY-P0163

Gramicidin 3 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic
Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

HY-111525

Monactin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Bacterial Antibiotic
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique *divalent cation* ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis** .

HY-N1378

(E)-Cardamonin 1 Publications Verification (E)-Cardamomin; (E)-Alpinetin chalcone	Chalcones Flavonoids Neurological Disease Classification of Application Fields Alpinia katsumadai Hayata Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Zingiberaceae	TRP Channel Apoptosis
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC₅₀ of 454 nM.

HY-75161

(-)-Menthol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Erythrina poeppigiana Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-13434

Ionomycin Maximum Cited Publications 48 Publications Verification SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium Maximum Cited Publications 48 Publications Verification SQ23377 calcium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-N8707

Homobutein	Classification of Application Fields Source classification Plants Compositae Infection Chalcones Flavonoids Millettia pachyloba Drake Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Parasite HDAC NF-κB
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-113469A

Cyclic GMP sodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺ . Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin . Nonactin inhibits the surface expression of endogenous HSP60 .

HY-129555

Surfactin 5 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial HSV Antibiotic
Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .

Species:	Human (3) Cat (3)
Tag:	His (4) SUMO (1) Tag Free (2)
Source:	HEK293 (1) P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P7744

	Catalase Protein, Human 1 Publications Verification rHuCATalase; CATalase; CAT	Human	E. coli
	Catalase Protein, Human is an approximately 60.0 kDa human catalase protein expressed in E.coli. Catalase is a key enzyme in metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors.

HY-P7744Y

	Catalase Protein, Human (solution) rHuCATalase; CATalase; CAT	Human	E. coli
	Catalase Protein, Human is an approximately 60.0 kDa human catalase protein expressed in E.coli. Catalase is a key enzyme in metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors.

HY-P701613

	CECR2 Protein, Human (His) CECR2; CAT eye syndrome critical region protein 2	Human	E. coli
	The CECR2 protein is a regulatory subunit in the CERF-1 and CERF-5 ISWI chromatin remodeling complexes that assembles ordered nucleosome arrays to help DNA enter replication, transcription, and repair. Despite lacking mononucleosome sliding ability, these complexes make crucial contributions to various developmental processes. CECR2 Protein, Human (His) is the recombinant human-derived CECR2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CECR2 Protein, Human (His) is 114 a.a., .

HY-P71780

	*Serum amyloid A protein, Cat* (P.pastoris, His)** SAA1; Serum amyloid A protein	Cat	P. pastoris
	Serum amyloid A is a major acute phase reactant, plays a dynamic role in the acute phase response and serves as an essential apolipoprotein in high-density lipoprotein (HDL) complexes. Enhanced expression during the acute phase response reflects its overall involvement in the body's adaptive response to different challenges. Serum amyloid A protein, Cat (P.pastoris, His) is the recombinant cat-derived Serum amyloid A protein, expressed by P. pastoris , with N-His labeled tag. The total length of Serum amyloid A protein, Cat (P.pastoris, His) is 90 a.a., with molecular weight of ~12.1 kDa.

HY-P71573

	*Allergen Fel d 4 Protein, Cat* (His-SUMO)** Allergen Fel d 4; allergen Fel d 4	Cat	E. coli
	Allergen Fel d 4 Protein, Cat (His-SUMO) is a recombinant protein with a His-SUMO tag. Fel d 4 is a lipocalin allergen produced by the cat, which binds IgE at relatively high frequency in cat-sensitive individuals.

HY-P700498

	*MSTN Protein, Cat* (HEK293, His)** myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8	Cat	HEK293
	MSTN (Myostatin) serves as a dedicated negative regulator of skeletal muscle growth, forming homodimers through disulfide linkages. It inhibits WFIKKN2 activity through interaction and further contributes to its role in negatively modulating skeletal muscle growth by engaging with FSTL3. MSTN Protein, Cat (HEK293, His) is the recombinant cat-derived MSTN protein, expressed by HEK293, with N-10*His labeled tag. The total length of MSTN Protein, Cat (HEK293, His) is 357 a.a., with molecular weight of 44.2 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0565S

Ronidazole-d3
Ronidazole-d₃is the deuterium labeledRonidazole(HY-B0565) . Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus?in cats models. Ronidazole can be used the research of forhistomoniasis?and?swine?dysentery .

HY-Y0682S

EDTA-d12

EDTA-d₁₂ is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

HY-Y0682S1

Ethylenediaminetetraacetic acid-d16

Ethylenediaminetetraacetic acid-d₁₆ is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-131897S

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
1-Stearoyl-2-Arachidonoyl-d₈-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P82000

GIT1 Antibody (YA1745)

ARF GAP GIT1; CAT 1; CAT1; GIT1
WB, FC Human, Mouse, Rat
HY-P81869

Cathepsin S Antibody (YA1614)

CTSS; CAThepsin S; CAT-s; CATS
WB, IHC-P, ICC/IF Human
HY-P82539

TrpV5 Antibody (YA2284)

CAT2; ECAC1; OTRPC3
WB, IP Human, Mouse, Rat


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