Hydroxydione

Cat. No.: HY-148156: FAQs
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Hydroxydione has an effect of general anesthetic. Hydroxydione is a neuroactive steroid it can be used for anaesthesia related research.

For research use only. We do not sell to patients.

Hydroxydione Chemical Structure

CAS No. : 303-01-5

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Description

Hydroxydione has an effect of general anesthetic. Hydroxydione is a neuroactive steroid it can be used for anaesthesia related research^[1]^[2].

In Vivo

Hydroxydione increases the duration of hexobarbital narcosis and repeats hexobarbital doses decrease the duration of hydroxydione narcosis^[1].
Hydroxydione (5-100 mg/kg; i.v. once) produces a transient hypotension with little bradycardia and affects the respiration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cats with chloralose 60 to 80 mg/kg^[2]
Dosage:	5-100 mg/kg
Administration:	Intravenous injection; 5-100 mg/kg once
Result:	Produce severe respiratory depression, but showed no effect on the tibialis in response to excitation of its motor nerve under the condition of chloralose. Produced the usual substantial sustained hypotension seen in chloralosed cats to response the nictitating membrane to preganglionic excitation with a dose of 10 mg/kg. Repressed the respiration in chloralosed cats after a rapid injection.

Molecular Weight

332.48

Formula

C₂₁H₃₂O₃

CAS No.

303-01-5

SMILES

C[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](CC(CC4)=O)([H])CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. RUMKE CL. The influence of drugs on the duration of hexobarbital and hydroxydione narcosis in mice. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1963;244:519-30. [Content Brief]

[2]. LERMAN LH, PATON WD. Experiments on the pharmacology of hydroxydione sodium succinate. Br J Pharmacol Chemother. 1960 Sep;15(3):458-65. [Content Brief]

Hydroxydione Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxydione303-01-5Othershexobarbitalnicotinegeneral anestheticanestheticneuroactivesteroidcatInhibitorinhibitorinhibit

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