1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity.
For research use only. We do not sell to patients.
- CAS No.: 2692624-31-8
- Formula: C41H64D8O5
- Molecular Weight:653.06
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Storage:
-80°C
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2692624-31-8
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Unlabeled CAS 65914-84-3
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Appearance Liquid
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Molecular Weight 653.06
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Formula C41H64D8O5
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Color Colorless to light yellow
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SMILES
CCCCCCCCCCCCCCCCCC(OC[C@@H](OC(CCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCC)=O)CO)=O
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Shipping
Shipping with dry ice.
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Storage
-80°C
Purity & Documentation
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Data Sheet (262 KB)
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SDS (546 KB)
- English - EN (546 KB)
- Français - FR (546 KB)
- Deutsch - DE (546 KB)
- Norwegian - NO (546 KB)
- Español - ES (546 KB)
- Swedish - SV (546 KB)
- Italian - IT (546 KB)
- Korean - KR (546 KB)
- Portuguese - PT (546 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1455-66. [Content Brief]
[3]. Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15(14):2595-601. [Content Brief]
[4]. Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol Related Classifications
HY-131897S Related Classifications
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