TrpV5 Antibody (YA2284)
(Synonyms: CAT2; ECAC1; OTRPC3)TrpV5 Antibody (YA2284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IP
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IP
IP: Immunoprecipitation
|
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:20 |
Product Details
TrpV5 Antibody (YA2284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 83 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 83 kDa
Entrez Gene: 56302 Human ; 194352 Mouse ; 116469 Rat
SwissProt: Q9NQA5 Human ; P69744 Mouse ; Q9JIP0 Rat
OMIM: 606679 Human
A synthetic peptide of human TRPV5
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
TrpV5 is a Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating[1][2].
-
Subcellular Localization
Apical cell membrane; Multi-pass membrane protein
-
Expression
Tissue_specificity:Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum -
Isoforms & Post-Translational Modification
Q9NQA5 has 2 isomers: Q9NQA5-1: 82562 Da (predicted); Q9NQA5-2: 43167 Da (predicted).
Glycosylated -
Subunit
Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation
-
SwissProt ID
-
Synonyms
CAT2; ECAC1; OTRPC3
-
Research Field
Signal Transduction
Documentation
Powered by Bioz
