1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPM4-IN-1

TRPM4-IN-1 (Synonyms: CBA)

Cat. No.: HY-122605
Handling Instructions

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer.

For research use only. We do not sell to patients.

TRPM4-IN-1 Chemical Structure

TRPM4-IN-1 Chemical Structure

CAS No. : 351424-20-9

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Description

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].

In Vitro

TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1].
TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells [1].
TRPM4-IN-1 is a potential chemical chaperone for TRPM4 loss-of-expression variant [1].
TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Partial rescued the total and surface expression of A432T.
Clinical Trial
Molecular Weight

340.16

Formula

C₁₅H₁₁Cl₂NO₄

CAS No.

351424-20-9

SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TRPM4-IN-1CBATRP ChannelTransient receptor potential channelscardiacdiseasesprostatecancercalcium-activatednon-selectivecationchannelTRPM4Inhibitorinhibitorinhibit

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TRPM4-IN-1
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