1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPM4-IN-1

TRPM4-IN-1 (Synonyms: CBA)

Cat. No.: HY-122605 Purity: 99.91%
Handling Instructions

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer.

For research use only. We do not sell to patients.

TRPM4-IN-1 Chemical Structure

TRPM4-IN-1 Chemical Structure

CAS No. : 351424-20-9

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Solution
10 mM * 1 mL in DMSO Check price and availability
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Description

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].

In Vitro

TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1].
TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells[1].
TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Partial rescued the total and surface expression of A432T.
Molecular Weight

340.16

Formula

C₁₅H₁₁Cl₂NO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (244.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9398 mL 14.6990 mL 29.3979 mL
5 mM 0.5880 mL 2.9398 mL 5.8796 mL
10 mM 0.2940 mL 1.4699 mL 2.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
TRPM4-IN-1
Cat. No.:
HY-122605
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