1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. TRPM4-IN-1

TRPM4-IN-1  (Synonyms: CBA)

Cat. No.: HY-122605 Purity: 99.91%
COA Handling Instructions

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer.

For research use only. We do not sell to patients.

TRPM4-IN-1 Chemical Structure

TRPM4-IN-1 Chemical Structure

CAS No. : 351424-20-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 85 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 85 In-stock
5 mg USD 49 In-stock
10 mg USD 77 In-stock
25 mg USD 165 In-stock
50 mg USD 275 In-stock
100 mg USD 440 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].

In Vitro

TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1].
? TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells[1].
? TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Partial rescued the total and surface expression of A432T.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (244.97 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9398 mL 14.6990 mL 29.3979 mL
5 mM 0.5880 mL 2.9398 mL 5.8796 mL
10 mM 0.2940 mL 1.4699 mL 2.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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