2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPM4-IN-1

TRPM4-IN-1  (Synonyms: CBA)

Cat. No.: HY-122605 Purity: 99.91%
COA Handling Instructions

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer.

For research use only. We do not sell to patients.

TRPM4-IN-1 Chemical Structure

TRPM4-IN-1 Chemical Structure

CAS No. : 351424-20-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 85 In-stock
Solid
5 mg USD 49 In-stock
10 mg USD 77 In-stock
25 mg USD 165 In-stock
50 mg USD 275 In-stock
100 mg USD 440 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TRPM4-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].

In Vitro

TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1].
? TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells[1].
? TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRPM4-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Partial rescued the total and surface expression of A432T.
Molecular Weight

340.16

Appearance

Solid

Formula

C15H11Cl2NO4
CAS No.
SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (244.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9398 mL 14.6990 mL 29.3979 mL
5 mM 0.5880 mL 2.9398 mL 5.8796 mL
10 mM 0.2940 mL 1.4699 mL 2.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TRPM4-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TRPM4-IN-1351424-20-9CBATRP ChannelTransient receptor potential channelscardiacdiseasesprostatecancercalcium-activatednon-selectivecationchannelTRPM4Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TRPM4-IN-1
Cat. No.:
HY-122605
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.