1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPM4-IN-1

TRPM4-IN-1 (Synonyms: CBA)

Cat. No.: HY-122605
Handling Instructions

CBA is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. CBA can be used for the research of cardiac diseases and prostate cancer.

For research use only. We do not sell to patients.

TRPM4-IN-1 Chemical Structure

TRPM4-IN-1 Chemical Structure

CAS No. : 351424-20-9

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Description

CBA is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. CBA can be used for the research of cardiac diseases and prostate cancer[1][2].

In Vitro

CBA is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells[1].
CBA reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells [1].
CBA is a potential chemical chaperone for TRPM4 loss-of-expression variant [1].
CBA (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant[1].

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: Overnight
Result: Partial rescued the total and surface expression of A432T.
Molecular Weight

340.16

Formula

C₁₅H₁₁Cl₂NO₄

CAS No.

351424-20-9

SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TRPM4-IN-1CBATRP ChannelTransient receptor potential channelscardiacdiseasesprostatecancercalcium-activatednon-selectivecationchannelTRPM4Inhibitorinhibitorinhibit

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