351424-20-9
351424-20-9
Chemical Structure
TRPM4-IN-1
Synonym(s): CBA
- CAS No.: 351424-20-9
- Formula:C15H11Cl2NO4
- Molecular Weight:340.16
IUPAC Name: 4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid
InChIKey: CVQCJPCMPGKEDH-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O
Biological Activity: TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].
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TRPM4-IN-1 | 99.17% | TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer. | ||||||||||||||||||||
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References
- [1]. Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175(12): 2504–2519. [Content Brief]
- [2]. Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177. [Content Brief]
Keywords
