1. Apoptosis
  2. Apoptosis
  3. NS3694

NS3694 

Cat. No.: HY-108356
Handling Instructions

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation.

For research use only. We do not sell to patients.

NS3694 Chemical Structure

NS3694 Chemical Structure

CAS No. : 426834-38-0

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Description

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].

In Vitro

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1].
NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1].
NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 120 min
Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
Molecular Weight

358.70

Formula

C15H10ClF3N2O3

CAS No.
SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(NC2=CC=CC(C(F)(F)F)=C2)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NS3694
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