2. Apoptosis
  3. Apoptosis
  4. NS3694

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation.

For research use only. We do not sell to patients.

NS3694 Chemical Structure

NS3694 Chemical Structure

CAS No. : 426834-38-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 290 In-stock
50 mg USD 420 In-stock
100 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

NS3694 Related Antibodies

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Description

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].

In Vitro

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1].
NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1].
NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NS3694 Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 120 min
Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.
Molecular Weight

358.70

Formula

C15H10ClF3N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(NC2=CC=CC(C(F)(F)F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (696.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7878 mL 13.9392 mL 27.8784 mL
5 mM 0.5576 mL 2.7878 mL 5.5757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7878 mL 13.9392 mL 27.8784 mL 69.6961 mL
5 mM 0.5576 mL 2.7878 mL 5.5757 mL 13.9392 mL
10 mM 0.2788 mL 1.3939 mL 2.7878 mL 6.9696 mL
15 mM 0.1859 mL 0.9293 mL 1.8586 mL 4.6464 mL
20 mM 0.1394 mL 0.6970 mL 1.3939 mL 3.4848 mL
25 mM 0.1115 mL 0.5576 mL 1.1151 mL 2.7878 mL
30 mM 0.0929 mL 0.4646 mL 0.9293 mL 2.3232 mL
40 mM 0.0697 mL 0.3485 mL 0.6970 mL 1.7424 mL
50 mM 0.0558 mL 0.2788 mL 0.5576 mL 1.3939 mL
60 mM 0.0465 mL 0.2323 mL 0.4646 mL 1.1616 mL
80 mM 0.0348 mL 0.1742 mL 0.3485 mL 0.8712 mL
100 mM 0.0279 mL 0.1394 mL 0.2788 mL 0.6970 mL
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NS3694 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS3694426834-38-0NS 3694NS-3694Apoptosisapoptosome inhibitorcytochrome cApaf-1caspase-9Inhibitorinhibitorinhibit

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