2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPM4-IN-2

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer.

For research use only. We do not sell to patients.

TRPM4-IN-2 Chemical Structure

TRPM4-IN-2 Chemical Structure

CAS No. : 667411-04-3

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Based on 1 publication(s) in Google Scholar

TRPM4-IN-2 Related Antibodies

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Description

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

IC50 & Target[1]

TRPM4

0.16 μM (IC50)

In Vitro

TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRPM4-IN-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: DU145
Concentration: 50 μM
Incubation Time: 0-500 s
Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
Molecular Weight

355.77

Formula

C19H14ClNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (281.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8108 mL 14.0540 mL 28.1080 mL
5 mM 0.5622 mL 2.8108 mL 5.6216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8108 mL 14.0540 mL 28.1080 mL 70.2701 mL
5 mM 0.5622 mL 2.8108 mL 5.6216 mL 14.0540 mL
10 mM 0.2811 mL 1.4054 mL 2.8108 mL 7.0270 mL
15 mM 0.1874 mL 0.9369 mL 1.8739 mL 4.6847 mL
20 mM 0.1405 mL 0.7027 mL 1.4054 mL 3.5135 mL
25 mM 0.1124 mL 0.5622 mL 1.1243 mL 2.8108 mL
30 mM 0.0937 mL 0.4685 mL 0.9369 mL 2.3423 mL
40 mM 0.0703 mL 0.3514 mL 0.7027 mL 1.7568 mL
50 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.4054 mL
60 mM 0.0468 mL 0.2342 mL 0.4685 mL 1.1712 mL
80 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8784 mL
100 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.7027 mL
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TRPM4-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPM4-IN-2667411-04-3NBATRP ChannelTransient receptor potential channelsTRPM4prostate cancercolorectal cancerDU145Inhibitorinhibitorinhibit

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