667411-04-3
667411-04-3
Chemical Structure
TRPM4-IN-2
Synonym(s): NBA
- CAS No.: 667411-04-3
- Formula:C19H14ClNO4
- Molecular Weight:355.77
IUPAC Name: 4-chloro-2-(2-(naphthalen-1-yloxy)acetamido)benzoic acid
InChIKey: OKFVCWAYHJMQFA-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O
Biological Activity: TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].
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TRPM4-IN-2 | 99.17% | TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. [Content Brief]
- [2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. [Content Brief]
Keywords
