CECR2 Protein, Human (His)

CECR2 protein functions as a regulatory subunit within the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which orchestrate the assembly of ordered nucleosome arrays on chromatin, facilitating DNA access during essential processes such as DNA replication, transcription, and repair. Despite lacking the capacity to slide mononucleosomes to the center of a DNA template, these complexes play crucial roles in various developmental processes. During embryogenesis, CECR2 is required for neural tube closure and inner ear development, while in adults, it is essential for spermatogenesis through the formation of ISWI-type chromatin complexes. Recognizing and binding acylated histones, CECR2 interacts with histones acetylated and/or butyrylated, contributing to histone-modifying complexes. Furthermore, its interaction with LRPPRC suggests involvement in integrating the cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling, and cytokinesis. As part of the CERF-1 and CERF-5 ISWI chromatin remodeling complexes, CECR2 collaborates with SMARCA1 and SMARCA5/SNF2H, respectively, highlighting its multifaceted role in chromatin dynamics and cellular processes.