1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor
  3. Adrenomedullin (AM) (22-52), human TFA

Adrenomedullin (AM) (22-52), human TFA (Synonyms: 22-52-Adrenomedullin (human) (TFA))

Cat. No.: HY-P1471A
Handling Instructions

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

For research use only. We do not sell to patients.

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Adrenomedullin (AM) (22-52), human TFA Chemical Structure

Adrenomedullin (AM) (22-52), human TFA Chemical Structure

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Description

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist. Adrenomedullin (AM) (22-52), human also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1].

IC50 & Target

Adrenomedullin receptor, CGRP receptor[1]

In Vitro

Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFA shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3690.06

Formula

C₁₆₁H₂₅₃N₄₆F₃O₅₀

Sequence

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

Sequence Shortening

TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Adrenomedullin (AM) (22-52), human22-52-Adrenomedullin (human) (TFA)CGRP ReceptorCalcitonin gene-related peptide receptoradrenomedullinreceptorcalcitoninpeptideCGRPhindlimbvascularbedcAMPaccumulationsmoothmuscleInhibitorinhibitorinhibit

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Adrenomedullin (AM) (22-52), human TFA
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HY-P1471A
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