2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. TRP Channel Endogenous Metabolite
  4. (-)-Menthol

(-)-Menthol 

Cat. No.: HY-75161 Purity: ≥98.0%
COA Handling Instructions

(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i. Antitumor activity.

For research use only. We do not sell to patients.

(-)-Menthol Chemical Structure

(-)-Menthol Chemical Structure

CAS No. : 2216-51-5

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10 mM * 1 mL in DMSO USD 61 In-stock
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10 mM * 1 mL
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Solid
500 mg USD 55 In-stock
1 g USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

(-)-Menthol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (-)-Menthol

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TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

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  • Customer Review

Description

(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

(-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1].
? (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1].
? Combination of 1α,25(OH)2D3 with (-)-Menthol? (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Menthol Related Antibodies
Molecular Weight

156.27

Appearance

Solid

Formula

C10H20O
CAS No.
SMILES

O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (639.92 mM; Need ultrasonic)

H2O : 1.89 mg/mL (12.09 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3992 mL 31.9959 mL 63.9918 mL
5 mM 1.2798 mL 6.3992 mL 12.7984 mL
10 mM 0.6399 mL 3.1996 mL 6.3992 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (207 KB) MS (72 KB)

Handling Instructions (2659 KB)
References
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(-)-Menthol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(-)-Menthol2216-51-5TRP ChannelEndogenous MetaboliteTransient receptor potential channelsInhibitorinhibitorinhibit

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