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  3. Edasalonexent

Edasalonexent (Synonyms: CAT-1004)

Cat. No.: HY-17630 Purity: 98.00%
Handling Instructions

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

For research use only. We do not sell to patients.

Edasalonexent Chemical Structure

Edasalonexent Chemical Structure

CAS No. : 1204317-86-1

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10 mM * 1 mL in DMSO USD 935 In-stock
Estimated Time of Arrival: December 31
5 mg USD 850 In-stock
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10 mg USD 1500 In-stock
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50 mg USD 4500 In-stock
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100 mg USD 6900 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

IC50 & Target

NF-κB[1]

In Vitro

Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB. Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model[2].

In Vivo

The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury[1].

Clinical Trial
Molecular Weight

490.68

Formula

C₃₁H₄₂N₂O₃

CAS No.

1204317-86-1

SMILES

O=C(NCCNC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)C1=CC=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
Animal Administration
[1]

Mice[1]
Male mdx or WT mice are used. Drug treatment protocols entail feeding individually housed mice a specialty control chow or chow containing either CAT-1041 or Edasalonexent (0.75% w/w) ad libitum starting at 4 weeks of age. Average drug consumption typically ranges between 0.75 and 1 mg/g body weight per day. The 24-hour plasma exposure at this dosage is 450ng hr/mL for Edasalonexent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Edasalonexent
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HY-17630
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