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Edasalonexent (Synonyms: CAT-1004)

Cat. No.: HY-17630 Purity: 98.0%
Handling Instructions

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

For research use only. We do not sell to patients.

Edasalonexent Chemical Structure

Edasalonexent Chemical Structure

CAS No. : 1204317-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 378 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.

IC50 & Target

NF-κB[1]

In Vitro

Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB. Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

490.68

Formula

C₃₁H₄₂N₂O₃

CAS No.

1204317-86-1

SMILES

O=C(NCCNC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)C1=CC=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (244.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0380 mL 10.1899 mL 20.3799 mL
5 mM 0.4076 mL 2.0380 mL 4.0760 mL
10 mM 0.2038 mL 1.0190 mL 2.0380 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]
Male mdx or WT mice are used. Drug treatment protocols entail feeding individually housed mice a specialty control chow or chow containing either CAT-1041 or Edasalonexent (0.75% w/w) ad libitum starting at 4 weeks of age. Average drug consumption typically ranges between 0.75 and 1 mg/g body weight per day. The 24-hour plasma exposure at this dosage is 450ng hr/mL for Edasalonexent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

EdasalonexentCAT-1004CAT1004CAT 1004NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Edasalonexent
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HY-17630
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