1. NF-κB
  2. NF-κB

Edasalonexent (Synonyms: CAT-1004)

Cat. No.: HY-17630 Purity: 98.00%
Handling Instructions

Edasalonexent is an orally bioavailable NF-κB inhibitor.

For research use only. We do not sell to patients.

Edasalonexent Chemical Structure

Edasalonexent Chemical Structure

CAS No. : 1204317-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 935 In-stock
Estimated Time of Arrival: December 31
5 mg USD 850 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 6900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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View All NF-κB Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Edasalonexent is an orally bioavailable NF-κB inhibitor.

IC50 & Target


In Vitro

Edasalonexent is an orally administered small molecule in which salicylic acid and docosahexaenoic acid (DHA) are covalently conjugated through an ethylenediamine linker and that is designed to synergistically leverage the ability of both of these compounds to inhibit NF-κB. Edasalonexent significantly inhibits NF-κB p65-dependent inflammatory responses as well as downstream proinflammatory genes modulated by p65 in the golden retriever duchenne muscular dystrophy (DMD) model[2].

In Vivo

The treatment of mdx mice with Edasalonexent for 20 weeks results in reduced susceptibility of the extensor digitorum longus muscle to eccentric contraction-induced injury[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0380 mL 10.1899 mL 20.3799 mL
5 mM 0.4076 mL 2.0380 mL 4.0760 mL
10 mM 0.2038 mL 1.0190 mL 2.0380 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Male mdx or WT mice are used. Drug treatment protocols entail feeding individually housed mice a specialty control chow or chow containing either CAT-1041 or Edasalonexent (0.75% w/w) ad libitum starting at 4 weeks of age. Average drug consumption typically ranges between 0.75 and 1 mg/g body weight per day. The 24-hour plasma exposure at this dosage is 450ng hr/mL for Edasalonexent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









-20°C, protect from light


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-17630