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Mildronate (Synonyms: Meldonium; MET-88; Quaterin)

Cat. No.: HY-B1836 Purity: >98.0%
Handling Instructions

Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes.

For research use only. We do not sell to patients.

Mildronate Chemical Structure

Mildronate Chemical Structure

CAS No. : 76144-81-5

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10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mildronate (Meldonium) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1].

IC50 & Target

IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).

Clinical Trial
Molecular Weight

146.19

Formula

C₆H₁₄N₂O₂

CAS No.

76144-81-5

SMILES

C[N+](C)(C)NCCC([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (342.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8404 mL 34.2021 mL 68.4041 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL
10 mM 0.6840 mL 3.4202 mL 6.8404 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

MildronateMeldonium MET-88 QuaterinMET88MET 88MET-88Othersischaemicβ-oxidationglycolysismitochondriaperoxisomessupplierInhibitorinhibitorinhibit

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Mildronate
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