2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Meldonium

Meldonium  (Synonyms: MET-88; Quaterin)

Cat. No.: HY-B1836 Purity: ≥98.0%
COA Handling Instructions

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Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor.

For research use only. We do not sell to patients.

Meldonium Chemical Structure

Meldonium Chemical Structure

CAS No. : 76144-81-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 35 In-stock
Solution
10 mM * 1 mL in Water USD 35 In-stock
Solid
50 mg USD 32 In-stock
100 mg USD 50 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Meldonium:

Meldonium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor[1][2].

IC50 & Target

IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).
In Vitro

Meldonium (20-40 μM; 24 h) ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meldonium Related Antibodies

RT-PCR[3]

Cell Line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
Concentration: 20, or 40 μM
Incubation Time: 24 h
Result: Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.

Western Blot Analysis[3]

Cell Line: Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
Concentration: 20, or 40 μM
Incubation Time: 24 h
Result: Significantly reduced the protein expression of PFKP, PKM2, and LDHA.
In Vivo

Meldonium (50, 100, or 200 mg/kg; once daily for 3 days) modestly attenuates hypoxia-induced lung injury in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

146.19

Formula

C6H14N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(C)NCCC([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (342.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.8404 mL 34.2021 mL 68.4041 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (684.04 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB) HNMR (240 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.8404 mL 34.2021 mL 68.4041 mL 171.0103 mL
5 mM 1.3681 mL 6.8404 mL 13.6808 mL 34.2021 mL
10 mM 0.6840 mL 3.4202 mL 6.8404 mL 17.1010 mL
15 mM 0.4560 mL 2.2801 mL 4.5603 mL 11.4007 mL
20 mM 0.3420 mL 1.7101 mL 3.4202 mL 8.5505 mL
25 mM 0.2736 mL 1.3681 mL 2.7362 mL 6.8404 mL
30 mM 0.2280 mL 1.1401 mL 2.2801 mL 5.7003 mL
40 mM 0.1710 mL 0.8551 mL 1.7101 mL 4.2753 mL
50 mM 0.1368 mL 0.6840 mL 1.3681 mL 3.4202 mL
60 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
80 mM 0.0855 mL 0.4275 mL 0.8551 mL 2.1376 mL
100 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7101 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Meldonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meldonium76144-81-5MET-88 QuaterinMET88MET 88Mitochondrial Metabolismischaemicβ-oxidationglycolysismitochondriaperoxisomessupplierInhibitorinhibitorinhibit

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