Meldonium (dihydrate)
Based on 5 publication(s) in Google Scholar
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor.
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- 純度: 99.0%
- CAS 番号: 86426-17-7
- 分子式: C6H18N2O4
- 分子量:182.22
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Meldonium dihydrate
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生物活性
IC50: 34-62 μM (human recombinant BBOX).
EC50: 21 μM (human OCTN2).
Meldonium (20-40 μM; 24 h) dihydrate ameliorates lung injury by targeting PFKP to regulate glycolysis, which promotes Nrf2 translocation from the cytoplasm to the nucleus to alleviate oxidative stress and mitochondrial damage under hypoxic condition[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
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Concentration:20, or 40 μM
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Incubation Time:24 h
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Result:Significantly decreased the mRNA expression of PFKP, PDK1, and PKM2 compared with the hypoxia group.
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Cell Line:Rat alveolar type II epithelial RLE-6TN cells in hypoxia incubator
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Concentration:20, or 40 μM
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Incubation Time:24 h
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Result:Significantly reduced the protein expression of PFKP, PKM2, and LDHA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 86426-17-7
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性状 Solid
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分子量 182.22
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分子式 C6H18N2O4
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Color White to off-white
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SMILES
C[N+](C)(C)NCCC([O-])=O.O.O
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別名
MET-88 (dihydrate); Quaterin (dihydrate)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Feb 11;16(1):1543. PMID: 39934163
Meldonium dihydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 11;16(1):1543. [Abstract]
Meldonium treatment of ccRCC cells attenuated the interaction between DCLK2 and BBOX1.
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Cell Rep Med
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization. [Abstract]2025 Dec 16;6(12):102507. PMID: 41406945 -
Neoplasia
BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression. [Abstract]2026 May:75:101299. PMID: 41875824
Meldonium dihydrate purchased from MedChemExpress. Usage Cited in: Neoplasia. 2026 May:75:101299. [Abstract]
Inhibition of BBOX1 reduced the migration ability of tumor cells. SNU-449 cells were treated with 100 mM Meldonium or PBS (vehicle) for 48 hours and then were employed to transwell assays.
Meldonium dihydrate purchased from MedChemExpress. Usage Cited in: Neoplasia. 2026 May:75:101299. [Abstract]
Meldonium treatment decreased the lung metastatic foci in mice. 1 × 10^6 B16-F10 melanoma cells were injected into C57BL/6 mice via tail vein. Three days after tumor inoculation, the mice were administered intraperitoneal injections at a dosage of 70 mg/kg meldonium once every two days and were euthanized 17 days later.
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J Anim Sci
2022 Apr 1;100(4):skac069. PMID: 35247050 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
溶剤 & 溶解度
H2O : 100 mg/mL (548.79 mM; Need ultrasonic)
DMSO : 4.85 mg/mL (26.62 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [Content Brief]
[2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. [Content Brief]
[3]. Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 5.4879 mL | 27.4394 mL | 54.8787 mL | 137.1968 mL |
| 5 mM | 1.0976 mL | 5.4879 mL | 10.9757 mL | 27.4394 mL | |
| 10 mM | 0.5488 mL | 2.7439 mL | 5.4879 mL | 13.7197 mL | |
| 15 mM | 0.3659 mL | 1.8293 mL | 3.6586 mL | 9.1465 mL | |
| 20 mM | 0.2744 mL | 1.3720 mL | 2.7439 mL | 6.8598 mL | |
| 25 mM | 0.2195 mL | 1.0976 mL | 2.1951 mL | 5.4879 mL | |
| H2O | 30 mM | 0.1829 mL | 0.9146 mL | 1.8293 mL | 4.5732 mL |
| 40 mM | 0.1372 mL | 0.6860 mL | 1.3720 mL | 3.4299 mL | |
| 50 mM | 0.1098 mL | 0.5488 mL | 1.0976 mL | 2.7439 mL | |
| 60 mM | 0.0915 mL | 0.4573 mL | 0.9146 mL | 2.2866 mL | |
| 80 mM | 0.0686 mL | 0.3430 mL | 0.6860 mL | 1.7150 mL | |
| 100 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3720 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Meldonium dihydrate 関連分類
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