5,5'-Difluoro BAPTA
5,5'-Difluoro BAPTA is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA is the most widely used probe for studying cytosolic free Ca2+ by 19F NMR. 5,5'-Difluoro BAPTA has high selectivity for Ca2+. 5,5'-Difluoro BAPTA can inhibit the growth of pollen tube.
For research use only. We do not sell to patients.
- CAS No.: 156027-00-8
- Formula: C34H38F2N2O18
- Molecular Weight:800.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5,5'-Difluoro BAPTA shows large 19F NMR chemical shifts upon chelating divalent cations[1].
Fe2+ ion concentrations were measured following addition of 5 mM 5,5'-Difluoro BAPTA to the culture medium. Fe2+ forms a complex with 5,5'-Difluoro BAPTA (Kd=50 nM) that exhibits a characteristic peak down-field from biological ions such as Ca2+ and Zn2+[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 156027-00-8
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Molecular Weight 800.66
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Formula C34H38F2N2O18
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SMILES
O=C(C)OCOC(CN(CC(OCOC(C)=O)=O)C1=CC(F)=CC=C1OCCOC2=CC=C(C=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bar-Shir A, et al. Metal ion sensing using ion chemical exchange saturation transfer 19F magnetic resonance imaging. J Am Chem Soc. 2013 Aug 21;135(33):12164-7. [Content Brief]
[2]. Pierson ES, et al. Pollen tube growth is coupled to the extracellular calcium ion flux and the intracellular calcium gradient: effect of BAPTA-type buffers and hypertonic media. Plant Cell. 1994 Dec;6(12):1815-28. [Content Brief]
[3]. Kostellow AB, et al. Iron-catalyzed lipid peroxidation in aortic cells in vitro: protective effect of extracellular magnesium. Atherosclerosis. 2004 Jul;175(1):15-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5,5'-Difluoro BAPTA Related Classifications
HY-147186 Related Classifications
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