1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
    Apoptosis
  2. Potassium Channel
    Mitochondrial Metabolism
    Apoptosis
  3. Nonactin

Nonactin (Synonyms: Ammonium ionophore I)

Cat. No.: HY-N6790 Purity: >99.0%
Handling Instructions

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+. Nonactin is able to uncouple the oxidative phosphorylation of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60.

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Nonactin Chemical Structure

Nonactin Chemical Structure

CAS No. : 6833-84-7

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10 mM * 1 mL in DMSO USD 730 In-stock
Estimated Time of Arrival: December 31
1 mg USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3].

Molecular Weight

736.93

Formula

C₄₀H₆₄O₁₂

CAS No.

6833-84-7

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

NonactinAmmonium ionophore IPotassium ChannelMitochondrial MetabolismApoptosisKcsAInhibitorinhibitorinhibit

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