2. Others Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic
  4. Nonactin

Nonactin  (Synonyms: Ammonium ionophore I)

Cat. No.: HY-N6790 Purity: ≥99.0%
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Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60.

For research use only. We do not sell to patients.

Nonactin Chemical Structure

Nonactin Chemical Structure

CAS No. : 6833-84-7

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1 mg USD 165 In-stock
5 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3].

Molecular Weight

736.93

Formula

C40H64O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@H](C)C[C@@]1([H])CC[C@@](O1)([H])[C@H](C)C(O[C@@H](C)C[C@]2([H])CC[C@](O2)([H])[C@@H](C)C(O[C@H](C)C[C@@]3([H])CC[C@@](O3)([H])[C@@H]4C)=O)=O)[C@H](C)[C@@](O5)([H])CC[C@@]5([H])C[C@H](C)OC4=O
Structure Classification
Initial Source

Streptomyces griseus ETH A7796
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 50 mg/mL (67.85 mM; ultrasonic and warming and heat to 60°C)

DMSO : 6.67 mg/mL (9.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3570 mL 6.7849 mL 13.5698 mL
5 mM 0.2714 mL 1.3570 mL 2.7140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 1.3570 mL 6.7849 mL 13.5698 mL 33.9245 mL
5 mM 0.2714 mL 1.3570 mL 2.7140 mL 6.7849 mL
DMF 10 mM 0.1357 mL 0.6785 mL 1.3570 mL 3.3925 mL
15 mM 0.0905 mL 0.4523 mL 0.9047 mL 2.2616 mL
20 mM 0.0678 mL 0.3392 mL 0.6785 mL 1.6962 mL
25 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3570 mL
30 mM 0.0452 mL 0.2262 mL 0.4523 mL 1.1308 mL
40 mM 0.0339 mL 0.1696 mL 0.3392 mL 0.8481 mL
50 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
60 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5654 mL
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Nonactin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nonactin6833-84-7Ammonium ionophore IOxidative PhosphorylationPotassium ChannelMitochondrial MetabolismBacterialInfluenza VirusApoptosisAntibioticKcsAInhibitorinhibitorinhibit

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