1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Tetraethylammonium chloride

Tetraethylammonium chloride 

Cat. No.: HY-B1793 Purity: >98.0%
Handling Instructions

Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.

For research use only. We do not sell to patients.

Tetraethylammonium chloride Chemical Structure

Tetraethylammonium chloride Chemical Structure

CAS No. : 56-34-8

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Description

Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties[1][2].

In Vitro

Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner[1].
Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells[1].
Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner[1].
The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium[1].

Cell Proliferation Assay[1]

Cell Line: Rat C6 and 9L glioma cells
Concentration: 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM
Incubation Time: 24 hours, 48 hours and 72 hours
Result: Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: Rat C6 and 9L glioma cells
Concentration: 40 mM
Incubation Time: 24 hours, 48 hours and 72 hours
Result: Significantly increased apoptosis in cells.

Western Blot Analysis[1]

Cell Line: Rat C6 and 9L glioma cells
Concentration: 40 mM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h.
In Vivo

Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days[2].

Molecular Weight

165.70

Formula

C₈H₂₀ClN

CAS No.

56-34-8

SMILES

CC[N+](CC)(CC)CC.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References
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Keywords:

TetraethylammoniumPotassium ChannelKcsABcl-2BaxantiproliferativeROSnon-selectiveantitumorcontractilityInhibitorinhibitorinhibit

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Tetraethylammonium chloride
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