Metelimumab
Based on 3 publication(s) in Google Scholar
Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1.
For research use only. We do not sell to patients.
- Purity: 98.98%
- CAS No.: 272780-74-2
- Molecular Weight:145.02 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Metelimumab
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Biological Activity
Human IgG4 kappa
Human
TGFB1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Immobilized TGF beta 1/TGFB1 Protein, Human can bind Metelimumab. The EC50 for this effect is 3.425 ng/mL. -
Flow Cytometry analysis of PC-3 cells labelling TGFB1 (red) with Metelimumab (anti-TGFB1) (HY-P99305). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 272780-74-2
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Appearance Liquid
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Molecular Weight 145.02 kDa
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Color Colorless to light yellow
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SMILES
[Metelimumab]
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Synonyms
CAT-192; Anti-TGFB1 Recombinant Antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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J Exp Clin Cancer Res
SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis. [Abstract]2024 Jul 27;43(1):208. PMID: 39061061 -
Matrix Biol
2024 Dec:134:132-143. PMID: 39393503 -
Toxicol Appl Pharmacol
Activation of the cGAS-STING pathway in monocytes exacerbates pulmonary fibrosis induced by paraquat poisoning. [Abstract]2025 Aug 9:504:117502. PMID: 40789441
Purity & Documentation
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Data Sheet (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)