1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Mito-apocynin (C11)

Mito-apocynin (C11) 

Cat. No.: HY-135869
Handling Instructions

Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function.

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Mito-apocynin (C11) Chemical Structure

Mito-apocynin (C11) Chemical Structure

CAS No. : 1254044-38-6

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Description

Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1].

In Vivo

Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice[1].

Animal Model: LRRK2R1441G mice[1]
Dosage: 3 mg/kg
Administration: Oral gavage; 3x/wk from 3 months of age until 15 months
Result: Markedly improved the coordinated motor function and olfactory function.
Molecular Weight

663.62

Formula

C₃₇H₄₄BrO₄P

CAS No.

1254044-38-6

SMILES

O=C(OCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=C(O)C(OC)=C4.[Br-]

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Keywords:

Mito-apocynin (C11)Mitochondrial MetabolismhyposmiadeficitsmotorParkinson’sdiseasemitochondria-targetedolfactoryneurodegenerationInhibitorinhibitorinhibit

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