1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Mito-apocynin (C11)

Mito-apocynin (C11) 

Cat. No.: HY-135869 Purity: 99.79%
Handling Instructions

Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function.

For research use only. We do not sell to patients.

Mito-apocynin (C11) Chemical Structure

Mito-apocynin (C11) Chemical Structure

CAS No. : 1254044-38-6

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Estimated Time of Arrival: December 31
100 mg USD 595 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1].

In Vivo

Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LRRK2R1441G mice[1]
Dosage: 3 mg/kg
Administration: Oral gavage; 3x/wk from 3 months of age until 15 months
Result: Markedly improved the coordinated motor function and olfactory function.
Molecular Weight

663.62

Formula

C₃₇H₄₄BrO₄P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (150.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5069 mL 7.5344 mL 15.0689 mL
5 mM 0.3014 mL 1.5069 mL 3.0138 mL
10 mM 0.1507 mL 0.7534 mL 1.5069 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Mito-apocynin (C11)
Cat. No.:
HY-135869
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