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Apocynin (Synonyms: Acetovanillone)

Cat. No.: HY-N0088 Purity: 99.86%
Handling Instructions

Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

For research use only. We do not sell to patients.

Apocynin Chemical Structure

Apocynin Chemical Structure

CAS No. : 498-02-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 80 In-stock
Estimated Time of Arrival: December 31
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Customer Review

    Apocynin purchased from MCE. Usage Cited in: Redox Biol. 2018 Jan 9;15:418-434.

    DPH oxidase inhibitor attenuates TSH-induced oxidative stress in HUVECs. NADPH oxidase inhibitor (Apocynin, 100 μM) is used to confirm the effects of NADPH oxidase activation in TSH-induced intracellular oxidative stress.
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    • References

    Description

    Apocynin is a selective NADPH-oxidase inhibitor with IC50 of 10 μM. apocynin is an intracellular inhibitor of the assembly of NADPH oxidase in neutrophils and eosinophils and that apocynin requires conversion by peroxidases to exert its inhibitory effec [1] Apocynin can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.[2] NADPH-oxidase is an enzyme responsible for reactive oxygen species production (ROS) and inhibition of this enzyme represents an attractive therapeutic target for the treatment of many diseases. [3]

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0179 mL 30.0897 mL 60.1793 mL
    5 mM 1.2036 mL 6.0179 mL 12.0359 mL
    10 mM 0.6018 mL 3.0090 mL 6.0179 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    166.17

    Formula

    C₉H₁₀O₃

    CAS No.

    498-02-2

    SMILES

    CC(C1=CC=C(O)C(OC)=C1)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.86%

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    Product Name:
    Apocynin
    Cat. No.:
    HY-N0088
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    Apocynin

    Cat. No.: HY-N0088