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  3. Apocynin

Apocynin (Synonyms: Acetovanillone)

Cat. No.: HY-N0088 Purity: 99.95%
Handling Instructions

Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.

For research use only. We do not sell to patients.

Apocynin Chemical Structure

Apocynin Chemical Structure

CAS No. : 498-02-2

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 80 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 11 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Apocynin purchased from MCE. Usage Cited in: Redox Biol. 2018 May;15:418-434.

    DPH oxidase inhibitor attenuates TSH-induced oxidative stress in HUVECs. NADPH oxidase inhibitor (Apocynin, 100 μM) is used to confirm the effects of NADPH oxidase activation in TSH-induced intracellular oxidative stress.

    Apocynin purchased from MCE. Usage Cited in: Free Radic Biol Med. 2021 Mar 16;S0891-5849(21)00113-1.

    Western Blots show that ZO-1 is significantly recovered with pretreatment of Apocynin and pathway inhibitors compared with CCL8 treatment alone. The result shows that with pretreatment of Apocynin, the increased phosphorylation p65 level induced by CCL8 is significantly weakened.
    • Biological Activity

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    Description

    Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.

    Clinical Trial
    Molecular Weight

    166.17

    Formula

    C₉H₁₀O₃

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (601.79 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0179 mL 30.0897 mL 60.1793 mL
    5 mM 1.2036 mL 6.0179 mL 12.0359 mL
    10 mM 0.6018 mL 3.0090 mL 6.0179 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.95%

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    Product Name:
    Apocynin
    Cat. No.:
    HY-N0088
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