498-02-2
498-02-2
Chemical Structure
Apocynin
Synonym(s): Acetovanillone
- CAS No.: 498-02-2
- Formula:C9H10O3
- Molecular Weight:166.18
IUPAC Name: 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one
InChIKey: DFYRUELUNQRZTB-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(O)C(OC)=C1)=O
Biological Activity: Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Apocynin | 99.93% | Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass. | ||||||||||||||||||||
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Apocynin (Standard) | ≥98% | Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass. | ||||||||||||||||||||
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Apocynin-d3 | Apocynin-d3 is the deuterium labeled Apocynin. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. | |||||||||||||||||||||
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References
- [1]. Stefanska J, et al. Mediators Inflamm, 2008, 106507. [Content Brief]
- [2]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102. [Content Brief]
- [3]. Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. [Content Brief]
- [4]. Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76(6):1177-81. [Content Brief]
- [5]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81(5):636-48. [Content Brief]
