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NQO1 activator 1 

Cat. No.: HY-128895
Handling Instructions

NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.

For research use only. We do not sell to patients.

NQO1 activator 1 Chemical Structure

NQO1 activator 1 Chemical Structure

CAS No. : 1800405-30-4

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Description

NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1].

IC50 & Target

NQO1[1]

Molecular Weight

240.26

Formula

C₁₄H₁₂N₂O₂

CAS No.

1800405-30-4

SMILES

O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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NQO1 activator 1
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HY-128895
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