KL1333 hydrochloride

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KL1333 hydrochloride is an orally active NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures.

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  • CAS No.: 1800406-26-1
  • Formula: C14H13ClN2O2
  • Molecular Weight:276.72
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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Publications Citing Use of MedChemExpress (MCE) KL1333 hydrochloride

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