1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Fumarate hydratase-IN-1

Fumarate hydratase-IN-1 

Cat. No.: HY-100004 Purity: 99.63%
Handling Instructions

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.

For research use only. We do not sell to patients.

Fumarate hydratase-IN-1 Chemical Structure

Fumarate hydratase-IN-1 Chemical Structure

CAS No. : 1644060-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 259 In-stock
Estimated Time of Arrival: December 31
2 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 384 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1176 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM[1].

IC50 & Target

Fumarate hydratase[1]

In Vitro

Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM[1].

Molecular Weight

446.54

Formula

C₂₇H₃₀N₂O₄

CAS No.

1644060-37-6

SMILES

O=C(OCC)[[email protected]]1([[email protected]](CC(NC)=O)C2=O)C(N2CC(C=C3)=CC=C3C4=CC=CC=C4)=CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (111.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2394 mL 11.1972 mL 22.3944 mL
5 mM 0.4479 mL 2.2394 mL 4.4789 mL
10 mM 0.2239 mL 1.1197 mL 2.2394 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.63%

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Keywords:

Fumarate hydratase-IN-1Mitochondrial MetabolismInhibitorinhibitorinhibit

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Fumarate hydratase-IN-1
Cat. No.:
HY-100004
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