2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Fumarate hydratase-IN-1

Fumarate hydratase-IN-1 

Cat. No.: HY-100004 Purity: 99.37%
COA Handling Instructions

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.

For research use only. We do not sell to patients.

Fumarate hydratase-IN-1 Chemical Structure

Fumarate hydratase-IN-1 Chemical Structure

CAS No. : 1644060-37-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 259 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 259 In-stock
Solid
2 mg USD 168 In-stock
5 mg USD 264 In-stock
10 mg USD 384 In-stock
50 mg USD 1176 In-stock
100 mg USD 1980 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Fumarate hydratase-IN-1 purchased from MCE. Usage Cited in: Nature. 2023 Mar 8.  [Abstract]

    Both Fumarate hydratase-IN-1 (FHIN1) and Dimethyl fumarate (DMF) treatment limit IFNβ-induced STAT1 and JAK1 phosphorylation in BMDMs.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM[1].

    IC50 & Target

    Fumarate hydratase[1]
    In Vitro

    Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    446.54

    Appearance

    Solid

    Formula

    C27H30N2O4
    CAS No.
    SMILES

    O=C(OCC)[[email protected]]1([[email protected]](CC(NC)=O)C2=O)C(N2CC(C=C3)=CC=C3C4=CC=CC=C4)=CCCC1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (111.97 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2394 mL 11.1972 mL 22.3944 mL
    5 mM 0.4479 mL 2.2394 mL 4.4789 mL
    10 mM 0.2239 mL 1.1197 mL 2.2394 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Fumarate hydratase-IN-11644060-37-6Mitochondrial MetabolismInhibitorinhibitorinhibit

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    Product Name:
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