1. Metabolic Enzyme/Protease
    Autophagy
  2. Mitochondrial Metabolism
    Autophagy
  3. VLX600

VLX600 

Cat. No.: HY-12406
Handling Instructions

VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity.

For research use only. We do not sell to patients.

VLX600 Chemical Structure

VLX600 Chemical Structure

CAS No. : 327031-55-0

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Description

VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].

In Vitro

VLX600 (6 μM; 72 hours) induces an autophagic response[2].
VLX600 is cytotoxic to HCT116 spheroids. VLX600 induces a HIF-1α-dependent glycolytic response. VLX600 inhibits oxygen consumption in HCT116 cells. VLX600 inhibits phosphorylation of the mTOR downstream effectors 4EBP1 and p70-S6K by an HIF-1α-independent mechanism. VLX600 preferentially leads to decreased ATP levels in cancer but not normal cells[2].

Cell Proliferation Assay[2]

Cell Line: HCT116, HT29, SW620, HT8, DLD and RKO cells
Concentration: 0.1, 1, 10, 100μM
Incubation Time: 72 hours
Result: Inhibited the proliferation of these cells.

Western Blot Analysis[2]

Cell Line: HCT116 cells
Concentration: 6 μM
Incubation Time: 72 hours
Result: LC3-II was induced.
In Vivo

VLX600 (16 mg/kg; i.v.; every third day for 16 days) shows anti-tumor activity in human tumor xenografts[2].

Animal Model: NMRI nu/nu mice (HCT116 and HT29 colon cancer xenografts)[2]
Dosage: 16 mg/kg
Administration: Intravenously; every third day for 16 days
Result: Anti-tumor activity was observed in both HCT116 and HT29 colon cancer xenografts.
Molecular Weight

317.35

Formula

C₁₇H₁₅N₇

CAS No.

327031-55-0

SMILES

CC1=C(NC2=C3N=NC(N/N=C(C4=CC=CC=N4)\C)=N2)C3=CC=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VLX600VLX 600VLX-600Mitochondrial MetabolismAutophagyironchelatoroxidative phosphorylationOXPHOSHCT116glycolyticcoloncancerproliferationInhibitorinhibitorinhibit

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VLX600
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HY-12406
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