1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. MCU-i4

MCU-i4 

Cat. No.: HY-138620 Purity: 99.38%
Handling Instructions

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target.

For research use only. We do not sell to patients.

MCU-i4 Chemical Structure

MCU-i4 Chemical Structure

CAS No. : 371924-24-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 400 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

In Vitro

MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].
MCU-i4 exerted a negative effect on Δψ. MCU-i4 has no effect on cell viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[1]

Cell Line: Growing medium of 90% confluent C2C12 myoblasts.
Concentration: 10 μM.
Incubation Time: 24 h.
Result: Decreased myotube width.
Molecular Weight

377.48

Formula

C₂₃H₂₇N₃O₂

CAS No.
SMILES

O=C(C1=C(NC2=CC=C(N(CC)CC)C=C2)C3=CC(C)=CC=C3N=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (33.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6491 mL 13.2457 mL 26.4915 mL
5 mM 0.5298 mL 2.6491 mL 5.2983 mL
10 mM 0.2649 mL 1.3246 mL 2.6491 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.25 mg/mL (3.31 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (3.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MCU-i4Mitochondrial MetabolismmitochondrialCa2+uptakeC2C12myoblastInhibitorinhibitorinhibit

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MCU-i4
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HY-138620
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