1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Ruthenium red

Ruthenium red (Synonyms: Ammoniated ruthenium oxychloride)

Cat. No.: HY-103311 Purity: ≥95.0%
Handling Instructions

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker.

For research use only. We do not sell to patients.

Ruthenium red Chemical Structure

Ruthenium red Chemical Structure

CAS No. : 11103-72-3

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100 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].

IC50 & Target

ICa[2]

In Vitro

Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2].
Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2].
Ruthenium red (10 μM) blocks the sarcoplasmic Ca release channels or the mitochondrial Ca uptake, and blocks 26.7 % of the sodium current, and slows its inactivation time-course in guinea-pig isolated ventricular heart cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1 mg/mL (Infinity mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: ≥95.0%

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Product Name:
Ruthenium red
Cat. No.:
HY-103311
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